Biology:Lig RNA thermometer
From HandWiki
Short description: Non-coding RNA in Leptospira interrogans
| Lig RNA thermometer | |
|---|---|
 Predicted secondary structure and sequence conservation of Lig thermometer | |
| Identifiers | |
| Rfam | RF02815 |
| Other data | |
| Domain(s) | Bacteria |
| GO | 0009266,0030371 |
| SO | 005836,0000204 |
| PDB structures | PDBe |
Lig RNA thermometer is a cis-acting non-coding RNA element that controls ligA and ligB gene expression in Leptospira interrogans in response to temperature change.[1] The lipoproteins LigA and LigB stimulate adhesion of the element and then hosting proteins.[2] The RNA that composes of 175-nucleotide 5'UTR and the first six lig codons (identical in ligA and ligB) folds into two distinct-stem loop structures. Lig expression is limited by these double-stranded RNA structures because they occludes the ribosome-binding site. At higher temperatures, the ribosome binding site is exposed to promote translation initiation.[1]
References
- ↑ 1.0 1.1 "Role for cis-acting RNA sequences in the temperature-dependent expression of the multiadhesive lig proteins in Leptospira interrogans". Journal of Bacteriology 195 (22): 5092–5101. November 2013. doi:10.1128/JB.00663-13. PMID 24013626.
- ↑ "Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogen". Infection and Immunity 75 (5): 2441–2450. May 2007. doi:10.1128/IAI.01635-06. PMID 17296754.
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