Biology:MAD2L2

Generic protein structure example

Mitotic spindle assembly checkpoint protein MAD2B is a protein that in humans is encoded by the MAD2L2 gene.

Function

MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L2 is a homolog of MAD2L1.

Interactions

MAD2L2 has been shown to interact with:

• ADAM9,
• MAD2L1,
• REV1, and
• REV3L.

Further reading

• "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J.. 343 343 (3): 673–680. 1999. doi:10.1042/0264-6021:3430673. PMID 10527948. 
• "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. 275 (6): 4391–4397. 2000. doi:10.1074/jbc.275.6.4391. PMID 10660610. 
• "Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B". Eur. J. Biochem. 268 (7): 2107–2112. 2001. doi:10.1046/j.1432-1327.2001.02091.x. PMID 11277934. 
• "MAD2B is an inhibitor of the anaphase-promoting complex". Genes Dev. 15 (14): 1765–1770. 2001. doi:10.1101/gad.898701. PMID 11459826. 
• "Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7". J. Biol. Chem. 276 (38): 35644–35651. 2001. doi:10.1074/jbc.M102051200. PMID 11485998. 
• "Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13808–13813. 2001. doi:10.1073/pnas.241304198. PMID 11717438. Bibcode: 2001PNAS...9813808W. 
• "Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins". J. Biol. Chem. 278 (14): 12356–12360. 2003. doi:10.1074/jbc.M211765200. PMID 12529368. 
• "Adenovirus ADP protein (E3–11.6K), which is required for efficient cell lysis and virus release, interacts with human MAD2B". Virology 313 (1): 224–234. 2003. doi:10.1016/S0042-6822(03)00287-3. PMID 12951035. 
• "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–167. 2004. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. 
• "Interaction of hREV1 with three human Y-family DNA polymerases". Genes Cells 9 (6): 523–531. 2004. doi:10.1111/j.1356-9597.2004.00747.x. PMID 15189446. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer". Int. J. Cancer 120 (1): 207–211. 2007. doi:10.1002/ijc.22155. PMID 17044027. 
• "Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1". Mol. Cell. Biol. 27 (8): 2861–2869. 2007. doi:10.1128/MCB.02276-06. PMID 17296730. 
• "Expression changes of the MAD mitotic checkpoint gene family in renal cell carcinomas characterized by numerical chromosome changes". Virchows Arch. 450 (4): 379–385. 2007. doi:10.1007/s00428-007-0386-7. PMID 17333263.