Biology:MAG1
From HandWiki
| 3-methyl-adenine DNA glycosylase [Saccharomyces cerevisiae] | |
|---|---|
| Identifiers | |
| Symbol | MAG1 |
| NCBI gene | 856885 |
| UniProt | P22134 |
| Other data | |
| EC number | 3.2.2.21 |
MAG1 is a gene in the yeast Saccharomyces cerevisiae that encodes DNA-3-methyladenine glycosylase, a monofunctional DNA N-glycosylase involved in base excision repair.[1][2][3] It initiates repair of alkylation damage and helps protect yeast cells from methylating agents.[2]
Function
MAG1 transcription is induced when yeast cells are exposed to relatively non-toxic levels of alkylating agents.[4] The encoded glycosylase has been reported to excise 3-methyladenine, 7-methylguanine, hypoxanthine, and 1,N6-ethenoadenine from DNA.[3]
References
- ↑ "Entrez Gene: MAG1: 3-methyl-adenine DNA glycosylase (Saccharomyces cerevisiae)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=856885.
- ↑ 2.0 2.1 "Bidirectional regulation of two DNA-damage-inducible genes, MAG1 and DDI1, from Saccharomyces cerevisiae". https://pubmed.ncbi.nlm.nih.gov/9157248/.
- ↑ 3.0 3.1 "DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae". https://academic.oup.com/genetics/article/193/4/1025/5935283.
- ↑ "Saccharomyces cerevisiae 3-methyladenine DNA glycosylase has homology to the AlkA glycosylase of E. coli and is induced in response to DNA alkylation damage". https://pmc.ncbi.nlm.nih.gov/articles/PMC552256/.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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