Biology:MAGEA1

Short description: Mammalian protein found in Homo sapiens

Generic protein structure example

Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene.

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.

Further reading

• "Identification of MAGE-1 and MAGE-4 proteins in spermatogonia and primary spermatocytes of testis". Cancer Res. 55 (16): 3478–82. 1995. PMID 7627949. 
• "Identification of potential CTL epitopes of tumor-associated antigen MAGE-1 for five common HLA-A alleles". Mol. Immunol. 31 (18): 1423–30. 1995. doi:10.1016/0161-5890(94)90158-9. PMID 7823968. 
• "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics 40 (5): 360–9. 1994. doi:10.1007/BF01246677. PMID 7927540. 
• "MAGE-1 gene product is a cytoplasmic protein". Int. J. Cancer 59 (3): 435–9. 1994. doi:10.1002/ijc.2910590324. PMID 7927954. 
• "Cloning and analysis of MAGE-1-related genes". Biochem. Biophys. Res. Commun. 202 (1): 549–55. 1994. doi:10.1006/bbrc.1994.1963. PMID 8037761. https://zenodo.org/record/1229420. 
• "Localization of the MAGE1 gene encoding a human melanoma antigen to chromosome Xq28". Cytogenet. Cell Genet. 67 (2): 116–9. 1994. doi:10.1159/000133810. PMID 8039421. https://zenodo.org/record/1235409. 
• "A member of the melanoma antigen-encoding gene (MAGE) family is expressed in human skin during wound healing". Int. J. Cancer 58 (3): 346–8. 1994. doi:10.1002/ijc.2910580306. PMID 8050815. 
• "Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes". J. Exp. Med. 179 (3): 921–30. 1994. doi:10.1084/jem.179.3.921. PMID 8113684. 
• "Identification of the MAGE-1 gene product by monoclonal and polyclonal antibodies". Proc. Natl. Acad. Sci. U.S.A. 91 (3): 1004–8. 1994. doi:10.1073/pnas.91.3.1004. PMID 8302824. Bibcode: 1994PNAS...91.1004C. 
• "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics 29 (3): 725–31. 1996. doi:10.1006/geno.1995.9945. PMID 8575766. 
• "HLA photoaffinity labeling reveals overlapping binding of homologous melanoma-associated gene peptides by HLA-A1, HLA-A29, and HLA-B44". J. Biol. Chem. 271 (21): 12463–71. 1996. doi:10.1074/jbc.271.21.12463. PMID 8647853. 
• "Identification of a promiscuous T-cell epitope encoded by multiple members of the MAGE family". Cancer Res. 59 (11): 2668–74. 1999. PMID 10363990. 
• "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Res. 10 (6): 758–75. 2000. doi:10.1101/gr.10.6.758. PMID 10854409. 
• "Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis". Cancer Res. 61 (21): 7959–63. 2001. PMID 11691819. 
• "The MAGE-A1 gene expression is not determined solely by methylation status of the promoter region in hematological malignancies". Leuk. Res. 26 (12): 1113–8. 2003. doi:10.1016/S0145-2126(02)00048-6. PMID 12443884. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity". J. Biol. Chem. 278 (12): 10668–74. 2003. doi:10.1074/jbc.M206104200. PMID 12525503. 
• "Ex vivo characterization of tumor-derived melanoma antigen encoding gene-specific CD8+cells in patients with hepatocellular carcinoma". J. Hepatol. 40 (1): 102–9. 2004. doi:10.1016/S0168-8278(03)00484-7. PMID 14672620. 
• "[The genetic polymorphism of melanoma-associated antigen 1 in Chinese normal donors and hepatoma patients]". Zhonghua Gan Zang Bing Za Zhi 12 (3): 151–5. 2004. PMID 15059299. 

External links

• Overview of all the structural information available in the PDB for UniProt: P43355 (Melanoma-associated antigen 1) at the PDBe-KB.