Biology:MAP3K11
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Short description: Protein-coding gene in humans
 Generic protein structure example |
Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene.[1][2]
Function
The protein encoded by this gene is called MLK3 and it is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates JNK and p38, and is found to be involved in the transcription activity of AP1 mediated by Rho family GTPases and CDC42.[3][4]
Interactions
MAP3K11 has been shown to interact with:
References
- ↑ "A 3-Mb Contig from D11S987 to MLK3, a Gene-Rich Region in 11q13". Genome Res 7 (8): 835–42. October 1997. doi:10.1101/gr.7.8.835. PMID 9267807.
- ↑ "MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain". Oncogene 9 (6): 1745–50. June 1994. PMID 8183572.
- ↑ "TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway". Genes Dev 25 (19): 2069–78. Oct 1, 2011. doi:10.1101/gad.17224711. PMID 21979919.
- ↑ "Entrez Gene: MAP3K11 mitogen-activated protein kinase kinase kinase 11". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4296.
- ↑ "Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival". J. Biol. Chem. 278 (6): 3897–902. February 2003. doi:10.1074/jbc.M211598200. PMID 12458207.
- ↑ "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. January 1998. doi:10.1093/emboj/17.1.149. PMID 9427749.
- ↑ "Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation". J. Biol. Chem. 275 (19): 14231–41. May 2000. doi:10.1074/jbc.275.19.14231. PMID 10799501.
- ↑ 8.0 8.1 "The JIP group of mitogen-activated protein kinase scaffold proteins". Mol. Cell. Biol. 19 (10): 7245–54. October 1999. doi:10.1128/mcb.19.10.7245. PMID 10490659.
- ↑ "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. November 2003. doi:10.1074/jbc.M307357200. PMID 14504284.
Further reading
- "Interactions of human immunodeficiency virus-1 proteins with neurons: possible role in the development of human immunodeficiency virus-1-associated dementia". Eur. J. Clin. Invest. 32 (8): 619–27. 2003. doi:10.1046/j.1365-2362.2002.01029.x. PMID 12190962.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity". J. Biol. Chem. 269 (21): 15092–100. 1994. doi:10.1016/S0021-9258(17)36578-X. PMID 8195146.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases". J. Biol. Chem. 273 (3): 1281–4. 1998. doi:10.1074/jbc.273.3.1281. PMID 9430657.
- "Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3". J. Biol. Chem. 273 (49): 32408–15. 1999. doi:10.1074/jbc.273.49.32408. PMID 9829970.
- "The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate". J. Biol. Chem. 274 (15): 10195–202. 1999. doi:10.1074/jbc.274.15.10195. PMID 10187804.
- "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol. Cell. Biol. 19 (10): 7245–54. 2000. doi:10.1128/mcb.19.10.7245. PMID 10490659.
- "Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3". Mol. Cell. Biol. 20 (3): 1030–43. 2000. doi:10.1128/MCB.20.3.1030-1043.2000. PMID 10629060.
- "Mixed-Lineage Kinase 3 Delivers CD3/CD28-Derived Signals into the IκB Kinase Complex". Mol. Cell. Biol. 20 (7): 2556–68. 2000. doi:10.1128/MCB.20.7.2556-2568.2000. PMID 10713178.
- "Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation". J. Biol. Chem. 275 (19): 14231–41. 2000. doi:10.1074/jbc.275.19.14231. PMID 10799501.
- "The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation". J. Biol. Chem. 276 (3): 1961–7. 2001. doi:10.1074/jbc.M004092200. PMID 11053428.
- "Chromosomal distribution, localization and expression of the human endogenous retrovirus ERV9". Cytogenet. Cell Genet. 92 (1–2): 89–96. 2001. doi:10.1159/000056875. PMID 11306803.
- "Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain". J. Biol. Chem. 276 (49): 45598–603. 2002. doi:10.1074/jbc.M107176200. PMID 11590155.
- "Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation". J. Biol. Chem. 277 (7): 4770–7. 2002. doi:10.1074/jbc.M109379200. PMID 11713255.
- "Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2". Mol. Cell. Biol. 22 (3): 737–49. 2002. doi:10.1128/MCB.22.3.737-749.2002. PMID 11784851.
- "Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping". Biochemistry 41 (17): 5613–24. 2002. doi:10.1021/bi016075c. PMID 11969422.
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