Biology:MAPEG family
| MAPEG family | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Crystal structure of human leukotriene C4 synthase. [1] | |||||||||||
| Identifiers | |||||||||||
| Symbol | MAPEG | ||||||||||
| Pfam | PF01124 | ||||||||||
| InterPro | IPR001129 | ||||||||||
| PROSITE | PS01297 | ||||||||||
| SCOP2 | 2pno / SCOPe / SUPFAM | ||||||||||
| OPM superfamily | 178 | ||||||||||
| OPM protein | 4yl3 | ||||||||||
| |||||||||||
In molecular biology the MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family of proteins are a group of membrane associated proteins with highly divergent functions.[2] Included are the 5-lipoxygenase-activating protein (gene FLAP), leukotriene C4 synthase (EC 2.5.1.37), which catalyzes the production of leukotriene C4 (LTC4) from leukotriene A4 (LTA4), and microsomal glutathione S-transferase II (EC 2.5.1.18) (GST-II), which also produces LTC4 from LTA4.
Another example is prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase, and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.
Subfamilies
Human proteins containing this domain
- 5-lipoxygenase-activating protein (ALOX5AP))
- LTC4S
- MGST1
- MGST2
- MGST3
- PTGES
References
- ↑ "Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis". Nature 448 (7153): 609–12. August 2007. doi:10.1038/nature05936. PMID 17632548. Bibcode: 2007Natur.448..609A.
- ↑ "Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism". Protein Science 8 (3): 689–92. March 1999. doi:10.1110/ps.8.3.689. PMID 10091672.
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