Biology:MAPK12

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Mitogen-activated protein kinase 12 (MAP kinase 12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.

Function

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.

Further reading

• "Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.". J. Am. Chem. Soc. 128 (17): 5913–22. 2006. doi:10.1021/ja060943h. PMID 16637659. 
• "Ras effectors and their role in mitogenesis and oncogenesis.". J. Mol. Med. 75 (8): 587–93. 1997. doi:10.1007/s001090050143. PMID 9297626. 
• "PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction.". Cancer Res. 70 (7): 2901–10. 2010. doi:10.1158/0008-5472.CAN-09-3229. PMID 20332238. 
• "Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection with human immunodeficiency virus type I.". J. Gen. Virol. 89 (Pt 7): 1661–71. 2008. doi:10.1099/vir.0.82971-0. PMID 18559936. 
• "p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock.". J. Cell Sci. 123 (Pt 15): 2596–604. 2010. doi:10.1242/jcs.066514. PMID 20605917. 
• "Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D₃.". Exp. Cell Res. 317 (1): 117–30. 2011. doi:10.1016/j.yexcr.2010.08.010. PMID 20804750. 
• "p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms.". J. Biol. Chem. 284 (17): 11237–46. 2009. doi:10.1074/jbc.M808327200. PMID 19251701. 
• "Hyperphosphorylation of tau in PHF.". Neurobiol. Aging 16 (3): 365–71; discussion 371–80. 1995. doi:10.1016/0197-4580(95)00027-C. PMID 7566346. 
• "Active mutants of the human p38alpha mitogen-activated protein kinase.". J. Biol. Chem. 279 (45): 47040–9. 2004. doi:10.1074/jbc.M404595200. PMID 15284239. 
• "Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription.". J. Biol. Chem. 282 (1): 91–9. 2007. doi:10.1074/jbc.M608012200. PMID 17088247. 
• "Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.". J. Cell Sci. 118 (Pt 11): 2355–62. 2005. doi:10.1242/jcs.02397. PMID 15923648. 
• "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.". Am. J. Hum. Genet. 85 (5): 628–42. 2009. doi:10.1016/j.ajhg.2009.10.014. PMID 19913121. 
• "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• "The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway.". J. Biol. Chem. 279 (46): 47652–60. 2004. doi:10.1074/jbc.M409961200. PMID 15342622. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response.". J. Biol. Chem. 282 (43): 31398–408. 2007. doi:10.1074/jbc.M703857200. PMID 17724032. 
• "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. 2004. doi:10.1186/gb-2004-5-10-r84. PMID 15461802. 
• "Loss of p38gamma MAPK induces pleiotropic mitotic defects and massive cell death.". J. Cell Sci. 124 (Pt 2): 216–27. 2011. doi:10.1242/jcs.068254. PMID 21172807. 
• "Nerve growth factor signaling, neuroprotection, and neural repair.". Annu. Rev. Neurosci. 24: 1217–81. 2001. doi:10.1146/annurev.neuro.24.1.1217. PMID 11520933. 
• "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.". Diabetes Care 33 (10): 2250–3. 2010. doi:10.2337/dc10-0452. PMID 20628086. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.