Biology:MAPKAP1
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 Generic protein structure example |
Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene.[1][2] As the name indicates, it is a subunit of mTOR complex 2.
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.[2]
References
- ↑ "Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene". Gene 339: 17–23. Sep 2004. doi:10.1016/j.gene.2004.07.001. PMID 15363842.
- ↑ 2.0 2.1 "Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79109.
Further reading
- Colicelli J; Nicolette C; Birchmeier C et al. (1991). "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2913–7. doi:10.1073/pnas.88.7.2913. PMID 1849280. Bibcode: 1991PNAS...88.2913C.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Jin J; Smith FD; Stark C et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- "The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins". Cell. Signal. 17 (6): 761–7. 2005. doi:10.1016/j.cellsig.2004.10.015. PMID 15722200.
- Benzinger A; Muster N; Koch HB et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- Cheng J; Zhang D; Kim K et al. (2005). "Mip1, an MEKK2-Interacting Protein, Controls MEKK2 Dimerization and Activation". Mol. Cell. Biol. 25 (14): 5955–64. doi:10.1128/MCB.25.14.5955-5964.2005. PMID 15988011.
- Venables JP; Bourgeois CF; Dalgliesh C et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon". Hum. Mol. Genet. 14 (16): 2289–303. doi:10.1093/hmg/ddi233. PMID 16000324.
- Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- Frias MA; Thoreen CC; Jaffe JD et al. (2006). "mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s". Curr. Biol. 16 (18): 1865–70. doi:10.1016/j.cub.2006.08.001. PMID 16919458.
- Jacinto E; Facchinetti V; Liu D et al. (2006). "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity". Cell 127 (1): 125–37. doi:10.1016/j.cell.2006.08.033. PMID 16962653.
- "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes Dev. 20 (20): 2820–32. 2006. doi:10.1101/gad.1461206. PMID 17043309.
- Makino C; Sano Y; Shinagawa T et al. (2007). "Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway". Genes Cells 11 (11): 1239–51. doi:10.1111/j.1365-2443.2006.01016.x. PMID 17054722.
- Olsen JV; Blagoev B; Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Schroder WA; Buck M; Cloonan N et al. (2007). "Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling". Cell. Signal. 19 (6): 1279–89. doi:10.1016/j.cellsig.2007.01.013. PMID 17303383.
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