Biology:MARK1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Serine/threonine-protein kinase MARK1 is an enzyme that in humans is encoded by the MARK1 gene.

Further reading

• "Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262.". J. Biol. Chem. 270 (13): 7679–88. 1995. doi:10.1074/jbc.270.13.7679. PMID 7706316. 
• "Protein kinase FA/glycogen synthase kinase-3 alpha after heparin potentiation phosphorylates tau on sites abnormally phosphorylated in Alzheimer's disease brain.". J. Neurochem. 63 (4): 1416–25. 1994. doi:10.1046/j.1471-4159.1994.63041416.x. PMID 7931292. 
• "Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics.". J. Biol. Chem. 271 (18): 10834–43. 1996. doi:10.1074/jbc.271.18.10834. PMID 8631898. 
• Paudel HK (1997). "The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase.". J. Biol. Chem. 272 (3): 1777–85. doi:10.1016/S0021-9258(19)67481-8. PMID 8999860. 
• "Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.". Arch. Biochem. Biophys. 357 (2): 299–309. 1998. doi:10.1006/abbi.1998.0813. PMID 9735171. 
• "Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase.". FEBS Lett. 436 (1): 28–34. 1998. doi:10.1016/S0014-5793(98)01090-4. PMID 9771888. 
• "New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry.". J. Neurochem. 71 (6): 2465–76. 1998. doi:10.1046/j.1471-4159.1998.71062465.x. PMID 9832145. 
• "Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments.". Biochemistry 38 (12): 3549–58. 1999. doi:10.1021/bi981874p. PMID 10090741. 
• "Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta.". J. Neurochem. 74 (4): 1587–95. 2000. doi:10.1046/j.1471-4159.2000.0741587.x. PMID 10737616. 
• "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143–50. 2000. doi:10.1093/dnares/7.2.143. PMID 10819331. 
• "Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta.". FEBS Lett. 530 (1–3): 209–14. 2002. doi:10.1016/S0014-5793(02)03487-7. PMID 12387894. 
• "Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5". Neuroscience 115 (3): 829–37. 2003. doi:10.1016/S0306-4522(02)00510-9. PMID 12435421. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1". EMBO J. 22 (19): 5090–101. 2003. doi:10.1093/emboj/cdg447. PMID 14517247. 
• "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes". J. Biol. Chem. 279 (7): 5915–23. 2004. doi:10.1074/jbc.M304528200. PMID 14594945. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. 2005. doi:10.1038/sj.emboj.7600110. PMID 14976552. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics 4 (6): 785–95. 2005. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.