Biology:MDR-NUDIX RNA motif
| MDR-NUDIX | |
|---|---|
 Consensus secondary structure and sequence conservation of MDR-NUDIX RNA | |
| Identifiers | |
| Symbol | MDR-NUDIX |
| Rfam | RF02918 |
| Other data | |
| RNA type | Cis-reg |
| SO | 0005836 |
| PDB structures | PDBe |
The MDR-NUDIX RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] The MDR-NUDIX motif is found in the poorly studied phylum TM7.
MDR-NUDIX motif RNAs likely function as cis-regulatory elements, in view of their positions upstream of protein-coding genes. Indeed, the RNAs are upstream of multiple genes that encode non-homologous proteins. If all examples of the RNA were upstream of homologous genes, there is the possibility that the RNAs were conserved in that position simply by inheritance. The non-homology of the genes downstream of MDR-NUDIX RNAs makes this scenario less likely. Most MDR-NUDIX RNAs are located upstream of genes that encode multidrug resistance transporters or the NUDIX protein domain, which is a hydrolase of various nucleoside diphosphate derivatives.
References
- ↑ "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. October 2017. doi:10.1093/nar/gkx699. PMID 28977401.
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