Biology:ME2 (gene)
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NAD-dependent malic enzyme, mitochondrial is a protein that in humans is encoded by the ME2 gene.[1][2] This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene.[2]
References
- ↑ "Human NAD(+)-dependent mitochondrial malic enzyme. cDNA cloning, primary structure, and expression in Escherichia coli". J Biol Chem 266 (5): 3016–21. Mar 1991. doi:10.1016/S0021-9258(18)49948-6. PMID 1993674.
- ↑ 2.0 2.1 "Entrez Gene: ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4200.
Further reading
- "Mitochondrial malic enzyme (E.C.1.1.1.40) in human leukocytes: formal genetics and population genetics.". Hum. Genet. 51 (3): 319–22. 1980. doi:10.1007/bf00283401. PMID 511162.
- "Further data on mitochondrial malic enzyme in man.". Hum. Hered. 28 (6): 421–5. 1978. doi:10.1159/000152993. PMID 680703.
- "Evidence for two distinct mitochondrial malic enzymes in human skeletal muscle: purification and properties of the NAD(P)+-dependent enzyme.". Biochim. Biophys. Acta 916 (3): 446–54. 1988. doi:10.1016/0167-4838(87)90191-9. PMID 3689803.
- "Different regulatory properties of the cytosolic and mitochondrial forms of malic enzyme isolated from human brain.". Int. J. Biochem. Cell Biol. 27 (10): 1003–8. 1996. doi:10.1016/1357-2725(95)00080-9. PMID 7496989.
- "Purification and properties of cytosolic and mitochondrial malic enzyme isolated from human brain.". Int. J. Biochem. Cell Biol. 27 (1): 47–54. 1995. doi:10.1016/1357-2725(94)00057-3. PMID 7757881.
- "Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme: a new class of oxidative decarboxylases.". Structure 7 (8): R877–89. 1999. doi:10.1016/S0969-2126(99)80115-4. PMID 10477256.
- "Structure of a closed form of human malic enzyme and implications for catalytic mechanism.". Nat. Struct. Biol. 7 (3): 251–7. 2000. doi:10.1038/73378. PMID 10700286.
- "Potent and competitive inhibition of malic enzymes by lanthanide ions.". Biochem. Biophys. Res. Commun. 274 (2): 440–4. 2000. doi:10.1006/bbrc.2000.3163. PMID 10913357.
- "Cloning and functional characterization of the 5' flanking region of the human mitochondrial malic enzyme gene. Regulatory role of Sp1 and AP-2.". Eur. J. Biochem. 268 (10): 3017–27. 2001. doi:10.1046/j.1432-1327.2001.02194.x. PMID 11358520.
- "Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus.". Genomics 72 (2): 169–79. 2001. doi:10.1006/geno.2000.6454. PMID 11401430.
- "Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate.". Structure 10 (7): 951–60. 2002. doi:10.1016/S0969-2126(02)00788-8. PMID 12121650.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. 2004. doi:10.1038/nbt810. PMID 12665801.
- "Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism.". Structure 11 (9): 1141–50. 2004. doi:10.1016/S0969-2126(03)00168-0. PMID 12962632.
- "Proteomic identification of brain proteins that interact with dynein light chain LC8.". Proteomics 4 (2): 339–46. 2004. doi:10.1002/pmic.200300528. PMID 14760703.
- "Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy.". Am. J. Hum. Genet. 76 (1): 139–46. 2005. doi:10.1086/426735. PMID 15532013.
- "Functional roles of ATP-binding residues in the catalytic site of human mitochondrial NAD(P)+-dependent malic enzyme.". Biochemistry 44 (38): 12737–45. 2005. doi:10.1021/bi050510b. PMID 16171388.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.