Biology:MED22
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Mediator of RNA polymerase II transcription subunit 22 is an enzyme that in humans is encoded by the MED22 gene.[1][2][3]
Function
This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.[3]
Interactions
MED22 has been shown to interact with MED30.[4]
References
- ↑ "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Human Molecular Genetics 2 (3): 237–40. Mar 1993. doi:10.1093/hmg/2.3.237. PMID 8499913.
- ↑ "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell 14 (5): 685–91. Jun 2004. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
- ↑ 3.0 3.1 "Entrez Gene: SURF5 surfeit 5". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6837.
- ↑ "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry 278 (17): 15123–7. Apr 2003. doi:10.1074/jbc.C300054200. PMID 12584197.
Further reading
- "Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene". Gene 126 (2): 227–35. Apr 1993. doi:10.1016/0378-1119(93)90371-9. PMID 8482538.
- "Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene". Genomics 30 (2): 163–70. Nov 1995. doi:10.1006/geno.1995.9889. PMID 8586415.
- "Tissue-specific processing of the Surf-5 and Surf-4 mRNAs". Gene Expression 6 (4): 209–18. 1997. PMID 9196076.
- "The human Surfeit locus". Genomics 52 (1): 72–8. Aug 1998. doi:10.1006/geno.1998.5372. PMID 9740673.
- "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts". Gene 284 (1–2): 169–78. Feb 2002. doi:10.1016/S0378-1119(02)00379-7. PMID 11891058.
- "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry 278 (17): 15123–7. Apr 2003. doi:10.1074/jbc.C300054200. PMID 12584197.
- "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal of Biological Chemistry 278 (50): 49671–4. Dec 2003. doi:10.1074/jbc.C300444200. PMID 14576168.
- "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry 279 (7): 5846–51. Feb 2004. doi:10.1074/jbc.M312523200. PMID 14638676.
- "An unappreciated role for RNA surveillance". Genome Biology 5 (2): R8. 2005. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
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