Biology:MIB1 (gene)
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E3 ubiquitin-protein ligase MIB1 is an enzyme that in humans is encoded by the MIB1 gene.[1] It is involved in regulating apoptosis.[2]
Confusion with proliferative marker
An antibody directed at the protein Ki-67, a product of the MKI67 gene, is called MIB-1.[3] The MIB1 gene, which regulates apoptosis, should not be confused with the MIB-1 antibody, which is used to measure Ki-67 expression.
References
- ↑ "Entrez Gene: MIB1 mindbomb homolog 1 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57534.
- ↑ MIB1. OMIM.URL: https://www.ncbi.nlm.nih.gov/omim/?term=608677. Accessed on: April 24, 2009.
- ↑ MIB-1. Veripath OncoDiagnostics. http://www.oncodx.org/onco/mib_1.htm . Accessed on: April 24, 2009.
Further reading
- "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. 2000. doi:10.1093/dnares/7.1.65. PMID 10718198.
- "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2.". J. Biol. Chem. 277 (15): 12622–31. 2002. doi:10.1074/jbc.M110568200. PMID 11812785.
- "A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK.". J. Biol. Chem. 277 (49): 46980–6. 2003. doi:10.1074/jbc.M208585200. PMID 12351649.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.". Dev. Cell 4 (1): 67–82. 2003. doi:10.1016/S1534-5807(02)00409-4. PMID 12530964.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Death-associated protein kinase expression in human temporal lobe epilepsy.". Ann. Neurol. 55 (4): 485–94. 2004. doi:10.1002/ana.20001. PMID 15048887.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Snx5, as a Mind bomb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish.". FEBS Lett. 580 (18): 4409–16. 2006. doi:10.1016/j.febslet.2006.07.009. PMID 16857196.
- "Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.". J. Biol. Chem. 281 (47): 36391–400. 2007. doi:10.1074/jbc.M606601200. PMID 17003037.
- "Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes.". J. Biol. Chem. 282 (16): 11795–804. 2007. doi:10.1074/jbc.M610430200. PMID 17324930.
- "Correlation of chromosomal imbalances by comparative genomic hybridization and expression of EGFR, PTEN, p53, and MIB-1 in diffuse gliomas.". Oncol. Rep. 17 (5): 1037–43. 2007. doi:10.3892/or.17.5.1037. PMID 17390041.
- "MIB1 expression in basal cell layer: a diagnostic tool to identify premalignancies of the vulva.". Mod. Pathol. 20 (7): 770–8. 2007. doi:10.1038/modpathol.3800796. PMID 17464313.
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