Biology:MPP5
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MAGUK p55 subfamily member 5 is a protein that in humans is encoded by the MPP5 gene.[1][2] Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM][2]
Interactions
MPP5 has been shown to interact with INADL and FAM71D.[1]
References
- ↑ 1.0 1.1 "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost". J Cell Biol 157 (1): 161–72. Apr 2002. doi:10.1083/jcb.200109010. PMID 11927608.
- ↑ 2.0 2.1 "Entrez Gene: MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64398.
Further reading
- "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "Molecular cloning and characterization of Pals, proteins associated with mLin-7.". J. Biol. Chem. 275 (15): 11425–31. 2000. doi:10.1074/jbc.275.15.11425. PMID 10753959.
- "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. 2001. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain.". Biochim. Biophys. Acta 1518 (3): 249–59. 2001. doi:10.1016/s0167-4781(01)00191-9. PMID 11311936.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).". Gene 302 (1–2): 21–9. 2003. doi:10.1016/S0378111902010843. PMID 12527193.
- "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly". Nat. Cell Biol. 5 (2): 137–42. 2003. doi:10.1038/ncb923. PMID 12545177.
- "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells". J. Cell Sci. 116 (Pt 14): 2895–906. 2004. doi:10.1242/jcs.00500. PMID 12771187.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex". Nat. Struct. Mol. Biol. 11 (11): 1122–7. 2004. doi:10.1038/nsmb839. PMID 15475968.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina". J. Comp. Neurol. 481 (1): 31–41. 2005. doi:10.1002/cne.20367. PMID 15558731. https://epub.uni-regensburg.de/35917/1/St-hr_et_al-2005-Journal_of_Comparative_Neurology.pdf.
- "A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins". Proc. Natl. Acad. Sci. U.S.A. 102 (19): 6861–6. 2005. doi:10.1073/pnas.0409346102. PMID 15863617. Bibcode: 2005PNAS..102.6861F.
- "MPP5 recruits MPP4 to the CRB1 complex in photoreceptors". Invest. Ophthalmol. Vis. Sci. 46 (6): 2192–201. 2005. doi:10.1167/iovs.04-1417. PMID 15914641.
- "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. 2006. doi:10.1093/nar/gkj139. PMID 16381901.
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