Biology:MS4A3
 Generic protein structure example |
Membrane-spanning 4-domains subfamily A member 3 is a protein that in humans is encoded by the MS4A3 gene.[1][2]
This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.[2]
Interactions
MS4A3 has been shown to interact with CDKN3.[3]
References
- ↑ "Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions". Proc Natl Acad Sci U S A 91 (21): 10178–82. Nov 1994. doi:10.1073/pnas.91.21.10178. PMID 7524084. Bibcode: 1994PNAS...9110178A.
- ↑ 2.0 2.1 "Entrez Gene: MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=932.
- ↑ Donato, José L; Ko Jon; Kutok Jeffery L; Cheng Tao; Shirakawa Taro; Mao Xiao-Quan; Beach David; Scadden David T et al. (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. (United States) 109 (1): 51–8. doi:10.1172/JCI14025. ISSN 0021-9738. PMID 11781350.
Further reading
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2.". J. Biol. Chem. 280 (17): 17235–42. 2005. doi:10.1074/jbc.M413437200. PMID 15671017.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Human HTm4 is a hematopoietic cell cycle regulator.". J. Clin. Invest. 109 (1): 51–8. 2002. doi:10.1172/JCI14025. PMID 11781350.
- "Structural organization of the human MS4A gene cluster on Chromosome 11q12.". Immunogenetics 53 (5): 357–68. 2001. doi:10.1007/s002510100339. PMID 11486273.
- "Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse.". Genomics 72 (2): 119–27. 2001. doi:10.1006/geno.2000.6472. PMID 11401424.
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