Biology:Metallochaperones
Metallochaperones are a distinct class of molecular chaperones that facilitate intracellular transport of metal ions to metalloenzymes and metalloproteins in cells through protein-protein interactions.[1] The proteins ensure that the correct metal ion cofactor is acquired by its corresponding metalloenzyme.[2] Metallochaperones are essential to the proper functioning of cells, playing a vital role in a large number of biological processes including respiration, photosynthesis, neurotransmission, and protein folding.[3]
Prior to the discovery of metallochaperones in the late 1990s, biologists believed that metal ions freely diffused within cells without the aid of auxiliary proteins.[2] Today, it is well established that these molecules contribute to the intracellular homeostatic control of biometal ions.[4]
References
- ↑ Rosenzweig, Amy C (2002-06-01). "Metallochaperones: Bind and Deliver". Chemistry & Biology 9 (6): 673–677. doi:10.1016/S1074-5521(02)00156-4. ISSN 1074-5521.
- ↑ 2.0 2.1 "Transition metal speciation in the cell: insights from the chemistry of metal ion receptors". Science 300 (5621): 931–6. 2003-05-09. doi:10.1126/science.1085049. PMID 12738850. Bibcode: 2003Sci...300..931F.
- ↑ Sekhon, Bhupinder Singh (2010-05-01). "Metallochaperones - an Overview" (in en). http://www.eurekaselect.com/93873/article.
- ↑ Kastenholz, Bernd (2008-04-29). "Phytochemical Approach and Bioanalytical Strategy to Develop Chaperone-Based Medications". The Open Biochemistry Journal 2: 44–48. doi:10.2174/1874091X00802010044.
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