Biology:Mitochondrial pyruvate carrier
From HandWiki
The mitochondrial pyruvate carriers are composed of:[1][2]
The pyruvate carriers are involved in mitochondrial metabolism but it is possible to compensate for their loss of function.[3] They have been studied for a role in cardiac stress adaption.[4]
Inhibitors
MPC inhibitors include drugs like UK-5099 (JXL001), JXL069, and PP405.[5][6]
References
- ↑ McCommis, Kyle S.; Finck, Brian N. (15 March 2015). "Mitochondrial pyruvate transport: a historical perspective and future research directions". Biochemical Journal 466 (3): 443–454. doi:10.1042/BJ20141171. PMID 25748677.
- ↑ "SLC54 Mitochondrial pyruvate carriers | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY". https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1006.
- ↑ Bender, Tom; Martinou, Jean-Claude (1 October 2016). "The mitochondrial pyruvate carrier in health and disease: To carry or not to carry?". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863 (10): 2436–2442. doi:10.1016/j.bbamcr.2016.01.017. ISSN 0167-4889. PMID 26826034. https://www.sciencedirect.com/science/article/pii/S0167488916300076.
- ↑ Zhang, Yuan; Taufalele, Paul V.; Cochran, Jesse D.; Robillard-Frayne, Isabelle; Marx, Jonas Maximilian; Soto, Jamie; Rauckhorst, Adam J.; Tayyari, Fariba et al. (November 2020). "Mitochondrial pyruvate carriers are required for myocardial stress adaptation" (in en). Nature Metabolism 2 (11): 1248–1264. doi:10.1038/s42255-020-00288-1. ISSN 2522-5812. PMID 33106689.
- ↑ "Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss". J Med Chem 64 (4): 2046–2063. February 2021. doi:10.1021/acs.jmedchem.0c01570. PMID 33534563.
- ↑ Brown, Lane (12 August 2025). "The Great Unbalding Draws Nearer". https://nymag.com/intelligencer/article/pp405-baldness-cure-hair-loss-treatment-follicles-science-tressless.html.
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