Biology:Mitochondrial translational release factor 1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.[1][2]
The protein encoded by this gene directs the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates. Alternatively, based on detailed 3D modelling, it has been proposed to recognize stalled ribosomes in which a tRNA is still bound to the peptide chain, but in which the A-site of the ribosome is empty.
References
- ↑ "Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1443 (1–2): 245–50. November 1998. doi:10.1016/S0167-4781(98)00223-1. PMID 9838146.
- ↑ "Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping". Cytogenetics and Cell Genetics 88 (1–2): 91–2. 2000. doi:10.1159/000015494. PMID 10773675.
Further reading
- "HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG.". Genes Cells 13 (5): 429–38. 2008. doi:10.1111/j.1365-2443.2008.01181.x. PMID 18429816.
- "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. 2004. doi:10.1038/nature02379. PMID 15057823. Bibcode: 2004Natur.428..522D.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Research 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nature Genetics 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proceedings of the National Academy of Sciences 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG.". Molecular Cell 27 (5): 745–57. 2007. doi:10.1016/j.molcel.2007.06.031. PMID 17803939.
- "Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria.". RNA 16 (6): 1146–55. 2010. doi:10.1261/rna.1970310. PMID 20421313.
- Huynen, MA, Martijn; Duarte I; Chrzanowska-Lightowlers ZM; Nabuurs SB. (8 May 2012). "Structure based hypothesis of a mitochondrial ribosome rescue mechanism.". Biology Direct 7 (1): 14. doi:10.1186/1745-6150-7-14. PMID 22569235.
- Lind, C; Sund J; Åqvist J (2013). "Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons.". Nature Communications 4: 2940. doi:10.1038/ncomms3940. PMID 24352605. Bibcode: 2013NatCo...4.2940L.
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