Biology:Monoamine activity enhancer
Monoamine activity enhancers (MAE), also known as catecholaminergic/serotoninergic activity enhancers, are a class neuro-biologically active compounds that enhance the release of monoamines in the nervous system. Monoamine activity enhancers are distinct from monoamine releasing agents in that they do not cause the release of monoamines from synaptic vesicles but rather potentiate impulse-evoked monoamine-release.[1][2] Monoamine activity enhancers increase the number of monoamines released per electrical impulse received.[1][2]
Endogenous monoamine activity enhancers
Monoamine activity enhancers can possess selectivity for enhancing the release of a certain monoamine over others. For example, the endogenous monoamine activity enhancer phenylethylamine (PEA) is roughly 100x more selective for potentiating dopamine release over serotonin release.[3] The monoamine potentiating effects of PEA are distinct from its monoamine releasing properties, which only present at high concentrations.[4] Conversely, another endogenous monoamine activity enhancer, tryptamine, appears to selectively potentiate serotonin release over dopamine release.[1]
Monoamine activity enhancing drugs
The Parkinson's disease drug selegiline (a phenylethylamine derivative) exhibits monoamine activity enhancing effects independent of its MAO inhibiting action.[4]
Mechanism of action
The mechanism of action of monoamine activity enhancers may be explained by their shared affinities for the trace amine 1 receptor.[1]
List of monoamine activity enhancers
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Shimazu, Seiichiro; Miklya, Ildikó (2004-05-01). "Pharmacological studies with endogenous enhancer substances: β-phenylethylamine, tryptamine, and their synthetic derivatives" (in en). Progress in Neuro-Psychopharmacology and Biological Psychiatry 28 (3): 421–427. doi:10.1016/j.pnpbp.2003.11.016. ISSN 0278-5846. PMID 15093948. https://www.sciencedirect.com/science/article/pii/S027858460300321X.
- ↑ 2.0 2.1 Bhattacharjee, Monojit; Perumal, Ekambaram (2019-03-01). "Potential plant-derived catecholaminergic activity enhancers for neuropharmacological approaches: A review" (in en). Phytomedicine 55: 148–164. doi:10.1016/j.phymed.2018.07.010. ISSN 0944-7113. PMID 30668425. https://www.sciencedirect.com/science/article/pii/S0944711318302642.
- ↑ 3.0 3.1 Nakamura, M.; Ishii, A.; Nakahara, D. (1998-05-22). "Characterization of beta-phenylethylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study". European Journal of Pharmacology 349 (2–3): 163–169. doi:10.1016/s0014-2999(98)00191-5. ISSN 0014-2999. PMID 9671094. https://pubmed.ncbi.nlm.nih.gov/9671094/.
- ↑ 4.0 4.1 Miklya, I. (November 2016). "The significance of selegiline/(-)-deprenyl after 50 years in research and therapy (1965-2015)". Molecular Psychiatry 21 (11): 1499–1503. doi:10.1038/mp.2016.127. ISSN 1476-5578. PMID 27480491.
- ↑ Magyar, Kálmán; Lengyel, Joseph; Bolehovszky, Andrea; Knoll, Bertha; Miklya, Iidikó; Knoll, Joseph (2002-09-01). "The fate of (−)1-(benzofuran-2-yl)-2-propylaminopentane · HCl, (−)-BPAP, in rats, a potent enhancer of the impulse-evoked release of catecholamines and serotonin in the brain" (in en). European Journal of Drug Metabolism and Pharmacokinetics 27 (3): 157–161. doi:10.1007/BF03190451. ISSN 2107-0180. PMID 12365195. https://doi.org/10.1007/BF03190451.
- ↑ Knoll, J.; Knoll, B.; Török, Z.; Timár, J.; Yasar, S. (1992). "The pharmacology of 1-phenyl-2-propylamino-pentane (PPAP), a deprenyl-derived new spectrum psychostimulant". Archives Internationales de Pharmacodynamie et de Therapie 316: 5–29. ISSN 0003-9780. PMID 1356324. https://pubmed.ncbi.nlm.nih.gov/1356324/.
- ↑ Shimazu, Seiichiro; Tanigawa, Akie; Sato, Noriyuki; Yoneda, Fumio; Hayashi, Kyozo; Knoll, Joseph (2003-05-02). "Enhancer substances: Selegiline and R-(–)-1-(benzofuran-2-yl)-2-propylaminopentane [(–)-BPAP enhance the neurotrophic factor synthesis on cultured mouse astrocytes"] (in en). Life Sciences 72 (24): 2785–2792. doi:10.1016/S0024-3205(03)00191-7. ISSN 0024-3205. PMID 12679194. https://www.sciencedirect.com/science/article/pii/S0024320503001917.
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