Biology:Mouse hepatitis virus
| Mouse hepatitis virus | |
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| Virus classification | |
| Group: | Group IV ((+)ssRNA)
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| Order: | |
| Family: | |
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| Genus: | |
| Species: | Murine coronavirus
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Mouse hepatitis virus is a virus of the family Coronaviridae, genus Betacoronavirus.
The Murine coronavirus, Mouse hepatitis virus (MHV), is a coronavirus that causes an epidemic murine illness with high mortality, especially among colonies of laboratory mice. Prior to the discovery of SARS-CoV, MHV had been the best-studied coronavirus both in vivo and in vitro as well as at the molecular level. Some strains of MHV cause a progressive demyelinating encephalitis in mice which has been used as a murine model for multiple sclerosis. Significant research efforts have been focused on elucidating the viral pathogenesis of these animal coronaviruses, especially by virologists interested in veterinary and zoonotic diseases.
References
- "Mouse Hepatitis Virus (MHV)". Division of Animal Resources, University of Illinois, Urbana. http://dar.research.illinois.edu/content/FactSheets/MHV.pdf.
Further reading
- Baker, David G. (1998). "Natural Pathogens of Laboratory Mice, Rats, and Rabbits and Their Effects on Research". Clinical Microbiology Reviews 11 (2): 231–66. doi:10.1128/CMR.11.2.231. PMID 9564563.
- Barthold, Stephen W.; Smith, Abigail L. (2006). "Mouse hepatitis virus". in Fox, James; Barthold; Davisson, Muriel et al.. The mouse in biomedical research: Volume 2 Diseases (2nd ed.). Burlington: Elsevier. pp. 141–178. ISBN 9780080467719.
Wikidata ☰ Q6926073 entry
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