Biology:Coronaviridae

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Virology[edit]

Diagram of coronavirus virion structure

Taxonomy[edit]

  • Coronaviridae
    • Letovirinae
      • Alphaletovirus
        • Milecovirus
          • Microhyla letovirus 1
    • Orthocoronavirinae
      • Alphacoronavirus
        • Colacovirus
          • Bat coronavirus CDPHE15
        • Decacovirus
          • Bat coronavirus HKU10
          • Rhinolophus ferrumequinum alphacoronavirus HuB-2013
        • Duvinacovirus
          • Human coronavirus 229E
        • Luchacovirus
          • Lucheng Rn rat coronavirus
        • Minacovirus
          • Ferret coronavirus
          • Mink coronavirus 1
        • Minunacovirus
          • Miniopterus bat coronavirus 1
          • Miniopterus bat coronavirus HKU8
        • Myotacovirus
          • Myotis ricketti alphacoronavirus Sax-2011
        • Nyctacovirus
          • Nyctalus velutinus alphacoronavirus SC-2013
        • Pedacovirus
          • Porcine epidemic diarrhea virus
          • Scotophilus bat coronavirus 512
        • Rhinacovirus
          • Rhinolophus bat coronavirus HKU2
        • Setracovirus
          • Human coronavirus NL63
          • NL63-related bat coronavirus strain BtKYNL63-9b
        • Tegacovirus
          • Alphacoronavirus 1
      • Betacoronavirus
        • Embecovirus
          • Betacoronavirus 1
          • China Rattus coronavirus HKU24
          • Human coronavirus HKU1
          • Murine coronavirus
        • Hibecovirus
          • Bat Hp-betacoronavirus Zhejiang2013
        • Merbecovirus
          • Hedgehog coronavirus 1
          • Middle East respiratory syndrome-related coronavirus
          • Pipistrellus bat coronavirus HKU5
          • Tylonycteris bat coronavirus HKU4
        • Nobecovirus
          • Rousettus bat coronavirus GCCDC1
          • Rousettus bat coronavirus HKU9
        • Sarbecovirus
          • Severe acute respiratory syndrome-related coronavirus
      • Deltacoronavirus
        • Andecovirus
          • Wigeon coronavirus HKU20
        • Buldecovirus
          • Bulbul coronavirus HKU11
          • Coronavirus HKU15
          • Munia coronavirus HKU13
          • White-eye coronavirus HKU16
        • Herdecovirus
          • Night heron coronavirus HKU19
        • Moordecovirus
          • Common moorhen coronavirus HKU21
      • Gammacoronavirus
        • Cegacovirus
          • Beluga whale coronavirus SW1
        • Igacovirus
          • Avian coronavirus

There are currently a total of 39 species assigned to this family.[1]

Transmission[edit]

Pathogenesis[edit]

SARS[edit]

Human infection by SARS coronavirus appears to be limited to the respiratory tract where infection of susceptible cells leads to damage to the pneumocytes resulting in a histological picture of diffuse alveolar damage and a clinical picture of adult respiratory distress syndrome. Diarrhea is also present but there is limited evidence of damage to the intestinal epithelium. The damage to the respiratory tree appears limited to the lower respiratory tract and there is evidence that the immune response plays a part in the outcome of patients with SARS.[2]

MERS[edit]

Middle Eastern Respiratory syndrome coronavirus (MERS-CoV), a betacoronavirus, was reported in 2012 in Saudi Arabia.[3] Although scientists have retroactively determined that the first case occurred in Jordan in 2012.[4] causes Middle Eastern Respiratory syndrome- a disease of the upper respiratory system. Typical symptoms include fever, cough, shortness of breath, and cold-like symptoms; more rare symptoms are pneumonia, gastroenteritis, and in worst cases, kidney failure.[3][5] The fatality rate in the 2012 outbreak was 30-40%.[5] Patients often die due to pulmonary edema in the final stages of the disease. The reservoir of the virus is still being investigated, but scientists believe it originated in bats and spread to camels; infections in humans are zoonotic.[3] Inter-human transmission appears to be via direct contact with low communicability; long term interaction with an infected individual seems to be very important for transmission.[4] Recent outbreaks have resulted from nosocomial infections and have been geographically limited to the Saudi peninsula (the 2015 South Korean outbreak originated with a traveler coming from Saudi Arabia).[6][7] Currently, there is no vaccine for MERS-CoV. There is no anti-viral treatment for MERS; most patients receive symptomatic treatment and supportive care for vital organ function.[8]

Many aspects of MERS are still being researched. Scientist have recently found that the cellular receptor for MERS-CoV is CD24, found in smooth muscle cells, pneumocytes, and bronchiolar epithelial cells.[9] There is a sensitive and specific RT-qPCR assay available for detection of MERS-CoV.[4]

Binding and entry[edit]

Coronaviruses bind to host cells primarily through interactions between viral spike glycoproteins and specific host cell surface glycoproteins. Some coronaviruses also bind to sialic acids on glycoproteins and glycolipids via their spike and/or hemaglutinin esterase glycoproteins. The interactions between coronaviruses and host cell receptors are critical determinants of species-specificity, tissue tropism, and virulence.[2][10]

Replication[edit]

The infection cycle of coronavirus

Coronaviruses have single-stranded, positive-sense RNA genomes of 26-30 kilobases, by far the largest non-segmented RNA virus genomes currently known. The key functions required for coronavirus RNA synthesis are encoded by the viral replicase gene. The gene comprises more than 20,000 nucleotides and encodes two replicase polyproteins, pp1a and pp1ab, that are proteolytically processed by viral proteases. Over the past years, it has become clear that the unique size of the coronavirus genome and the special mechanism that coronaviruses (and several other nidoviruses) have evolved to produce an extensive set of subgenome-length RNAs is linked to the production of a number of nonstructural proteins (nsps) that is unprecedented among RNA viruses. Many of these replicase cleavage products are in fact multidomain proteins themselves, thus further increasing the complexity of protein functions and interactions. Structural studies suggest that several nsps, following their release from larger precursor molecules, form dimers or even multimers. The various pp1a/pp1ab precursors and processing products are thought to assemble into large, membrane-associated complexes that, in a temporally coordinated manner, catalyze the reactions involved in RNA replication and transcription and, it is presumed, serve yet other functions in the viral life cycle.[10][2][11]

Coronaviruses also exhibit ribosomal frameshifting and polymerase stuttering as part of their complex replicative cycle.[12][13][14][15][16]

Genomic cis-acting elements[edit]

In common with the genomes of all other RNA viruses, coronavirus genomes contain cis-acting RNA elements that ensure the specific replication of viral RNA by a virally encoded RNA-dependent RNA polymerase. The embedded cis-acting elements devoted to coronavirus replication constitute a small fraction of the total genome, but this is, it is presumed, a reflection of the fact that coronaviruses have the largest genomes of all RNA viruses. The boundaries of cis-acting elements essential to replication are fairly well-defined, and an increasingly well-resolved picture of the RNA secondary structures of these regions is emerging. However, we are in only the early stages of understanding how these cis-acting structures and sequences interact with the viral replicase and host cell components, and much remains to be done before we understand the precise mechanistic roles of such elements in RNA synthesis.[10][2]

Genome packaging[edit]

The assembly of infectious coronavirus particles requires the selection of viral genomic RNA from a cellular pool that contains an abundant excess of non-viral and viral RNAs. Among the seven to ten specific viral mRNAs synthesized in virus-infected cells, only the full-length genomic RNA is packaged efficiently into coronavirus particles. Studies have revealed cis-acting elements and trans-acting viral factors involved in coronavirus genome encapsidation and packaging. Understanding the molecular mechanisms of genome selection and packaging is critical for developing antiviral strategies and viral expression vectors based on the coronavirus genome.[10][2]

References[edit]

  1. "Virus Taxonomy: 2018 Release" (in en) (html). October 2018. https://talk.ictvonline.org/taxonomy/. Retrieved 24 January 2019. 
  2. 2.0 2.1 2.2 2.3 2.4 Thiel V (editor). (2007). Coronaviruses: Molecular and Cellular Biology (1st ed.). Caister Academic Press. [1]. ISBN 978-1-904455-16-5. http://www.horizonpress.com/cor. 
  3. 3.0 3.1 3.2 "Middle East respiratory syndrome coronavirus (MERS-CoV)" (in en-GB). http://www.who.int/mediacentre/factsheets/mers-cov/en/. 
  4. 4.0 4.1 4.2 Mackay, Ian M.; Arden, Katherine E. (2015-12-22). "MERS coronavirus: diagnostics, epidemiology and transmission" (in En). Virology Journal 12 (1): 222. doi:10.1186/s12985-015-0439-5. ISSN 1743-422X. PMID 26695637. 
  5. 5.0 5.1 "MERS-CoV | Symptoms and Complications of MERS | Coronavirus | CDC". https://www.cdc.gov/coronavirus/mers/about/symptoms.html. 
  6. "MERS-CoV | About MERS | Middle East Respiratory Syndrome | CDC". https://www.cdc.gov/coronavirus/mers/about/index.html. 
  7. "Tracking MERS-CoV Transmission | NIH: National Institute of Allergy and Infectious Diseases". https://www.niaid.nih.gov/diseases-conditions/tracking-mers-cov-transmission. 
  8. "MERS-CoV | Prevention and Treatment of MERS | Coronavirus | CDC". https://www.cdc.gov/coronavirus/mers/about/prevention.html. 
  9. Falzarano, Darryl; Wit, Emmie de; Feldmann, Friederike; Rasmussen, Angela L.; Okumura, Atsushi; Peng, Xinxia; Thomas, Matthew J.; Doremalen, Neeltje van et al. (2014-08-21). "Infection with MERS-CoV Causes Lethal Pneumonia in the Common Marmoset". PLOS Pathogens 10 (8): e1004250. doi:10.1371/journal.ppat.1004250. ISSN 1553-7374. PMID 25144235. 
  10. 10.0 10.1 10.2 10.3 "Family Coronaviridae". In: Ninth Report of the International Committee on Taxonomy of Viruses. AMQ King, E Lefkowitz, MJ Adams, and EB Carstens (Eds), Elsevier, Oxford, pp. 806-828. 2011. ISBN 978-0-12-384684-6. 
  11. Enjuanes L (2008). "Coronavirus Replication and Interaction with Host". Animal Viruses: Molecular Biology. Caister Academic Press. ISBN 978-1-904455-22-6. http://www.horizonpress.com/hsp/abs/absavir.html. 
  12. Namy O, Moran SJ, Stuart DI, Gilbert RJ, Brierley I. "A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting." Nature. 2006 May 11;441(7090):244-7.
  13. Plant, EP; Dinman, JD (Apr 2006). "Comparative study of the effects of heptameric slippery site composition on -1 frameshifting among different eukaryotic systems". RNA 12 (4): 666–73. doi:10.1261/rna.2225206. PMID 16497657. 
  14. "An atypical RNA pseudoknot stimulator and an upstream attenuation signal for -1 ribosomal frameshifting of SARS coronavirus". Nucleic Acids Research 33 (13): 4265–75. 2005. doi:10.1093/nar/gki731. PMID 16055920. PMC 1182165. http://assets0.pubget.com/paper/16055920/An_atypical_RNA_pseudoknot_stimulator_and_an_upstream_attenuation_signal_for__1_ribosomal_frameshifting_of_SARS_coronavirus?from=16055920&q=issn%3A0305-1048+vol%3A33+issue%3A13. 
  15. Herrewgh, A.A.; Vennema, H.; Horzinek, M.C.; Rottier, P.J; de Groot, R.J. (1995). "The molecular genetics of feline coronaviruses: comparative sequence analysis of the ORF7a/7b transcription unit of different biotypes". Virology 212 (2): 622–31. doi:10.1006/viro.1995.1520. PMID 7571432. http://www.biosino.org/feidian/SARS-bingduwenxian/1-034.pdf. 
  16. Jeong, YS; Makino, S (Apr 1994). "Evidence for coronavirus discontinuous transcription". J Virol 68 (4): 2615–23. doi:10.1128/JVI.68.4.2615-2623.1994. PMID 8139040. 

External links[edit]

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https://en.wikipedia.org/wiki/Coronaviridae was the original source. Read more.