Biology:Multicellular tumor spheroids
From HandWiki
Multicellular tumor spheroids are scaffold-free spherical self-assembled aggregates of cancer cells.[1] It is a 3 dimensional culture model which closely models oxygen gradients in small avascular tumors. They are cellular model used in cancer research to assess drug response.
References
- ↑ Santani, M T; Rainaldi, G; Indovina, P L (July 1999). "Multicellular tumour spheroids in radiation biology". International Journal of Radiation Biology 75 (7): 787–799. doi:10.1080/095530099139845. PMID 10489890. https://pubmed.ncbi.nlm.nih.gov/10489890/.
Further reading
- Lazzari, Gianpiero; Couvreur, Patrick; Mura, Simona (2017). "Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines". Polymer Chemistry 8 (34): 4947–4969. doi:10.1039/C7PY00559H.
- Carver, Kyle; Ming, Xin; Juliano, Rudolph L. (1 January 2014). "Multicellular Tumor Spheroids as a Model for Assessing Delivery of Oligonucleotides in Three Dimensions". Molecular Therapy: Nucleic Acids 3 (3): e153. doi:10.1038/mtna.2014.5. PMID 24618852.
- Hirschhaeuser, Franziska; Menne, Heike; Dittfeld, Claudia; West, Jonathan; Mueller-Klieser, Wolfgang; Kunz-Schughart, Leoni A. (1 July 2010). "Multicellular tumor spheroids: An underestimated tool is catching up again". Journal of Biotechnology 148 (1): 3–15. doi:10.1016/j.jbiotec.2010.01.012. PMID 20097238.
- Yuhas, John M.; Li, Albert P.; Martinez, Andrew O.; Ladman, Aaron J. (1 October 1977). "A Simplified Method for Production and Growth of Multicellular Tumor Spheroids". Cancer Research 37 (10): 3639–3643. PMID 908012. https://cancerres.aacrjournals.org/content/37/10/3639.short.
- Kelm, Jens M.; Timmins, Nicholas E.; Brown, Catherine J.; Fussenegger, Martin; Nielsen, Lars K. (20 July 2003). "Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types". Biotechnology and Bioengineering 83 (2): 173–180. doi:10.1002/bit.10655. PMID 12768623.
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