Biology:N-hydroxy-2-acetamidofluorene reductase
From HandWiki
| N-hydroxy-2-acetamidofluorene reductase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.7.1.12 | ||||||||
| CAS number | 99890-08-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a N-hydroxy-2-acetamidofluorene reductase (EC 1.7.1.12) is an enzyme that catalyzes the chemical reaction
- 2-acetamidofluorene + NAD(P)+ + H2O [math]\displaystyle{ \rightleftharpoons }[/math] N-hydroxy-2-acetamidofluorene + NAD(P)H + H+
The 4 substrates of this enzyme are 2-acetamidofluorene, NAD+, NADP+, and H2O, whereas its 4 products are N-hydroxy-2-acetamidofluorene, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-acetamidofluorene:NAD(P)+ oxidoreductase. Other names in common use include N-hydroxy-2-acetylaminofluorene reductase, and NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase.
References
- "The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver in vitro. An inducible enzymatic reaction". J. Biol. Chem. 244 (7): 1729–40. 1969. PMID 5780838.
- "Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol". Biochem. Biophys. Res. Commun. 133 (1): 67–74. 1985. doi:10.1016/0006-291X(85)91842-X. PMID 4074379.
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