Biology:N6AMT1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

N-6 adenine-specific DNA methyltransferase 1 is a protein that in humans is encoded by the N6AMT1 gene.

Function

The N6AMT1 gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014]. N6AMT1 functions as a protein glutamine methyltransferase and is essential for mouse development (Liu et al., Mol. Cell. Biol. 2010).

Further reading

• "HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1". FEBS Lett. 582 (16): 2352–6. July 2008. doi:10.1016/j.febslet.2008.05.045. PMID 18539146. Bibcode: 2008FEBSL.582.2352F. 
• "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. 2010. doi:10.2119/molmed.2009.00159. PMID 20379614. 
• "Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity". Environ. Health Perspect. 119 (6): 771–7. June 2011. doi:10.1289/ehp.1002733. PMID 21193388. Bibcode: 2011EnvHP.119..771R. 
• "N-6-adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms and arsenic methylation in Andean women". Environ. Health Perspect. 121 (7): 797–803. July 2013. doi:10.1289/ehp.1206003. PMID 23665909. Bibcode: 2013EnvHP.121..797H. 
• "Interactive Influence of N6AMT1 and As3MT Genetic Variations on Arsenic Metabolism in the Population of Inner Mongolia, China". Toxicol. Sci. 155 (1): 124–134. January 2017. doi:10.1093/toxsci/kfw181. PMID 27637898. 

Peng Liu, Song Nie, Bing Li, Zhong-Qiang Yang, Zhi-Mei Xu, Jian Fei, Chyuansheng Lin, Rong Zeng, and Guo-Liang Xu. Deficiency in a Glutamine-Specific Methyltransferase for Release Factor Causes Mouse Embryonic Lethality. MOLECULAR AND CELLULAR BIOLOGY, Sept. 2010, p. 4245–4253 Vol. 30, No. 17 0270-7306/10/

This article incorporates text from the United States National Library of Medicine, which is in the public domain.