Biology:NAP1L4
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Nucleosome assembly protein 1-like 4 is a protein that in humans is encoded by the NAP1L4 gene.[1][2]
This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.[2]
References
- ↑ "A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues". Hum Mol Genet 5 (11): 1743–8. Mar 1997. doi:10.1093/hmg/5.11.1743. PMID 8923002.
- ↑ 2.0 2.1 "Entrez Gene: NAP1L4 nucleosome assembly protein 1-like 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4676.
Further reading
- "Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone.". Genomics 44 (3): 253–65. 1997. doi:10.1006/geno.1997.4868. PMID 9325046.
- "NAP-2: histone chaperone function and phosphorylation state through the cell cycle.". J. Mol. Biol. 298 (2): 225–38. 2000. doi:10.1006/jmbi.2000.3674. PMID 10764593.
- "Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators.". Mol. Cell. Biol. 20 (23): 8933–43. 2000. doi:10.1128/MCB.20.23.8933-8943.2000. PMID 11073993.
- "HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication.". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9380–5. 2002. doi:10.1073/pnas.142287999. PMID 12089333. Bibcode: 2002PNAS...99.9380C.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "NAP-2 is part of multi-protein complexes in HeLa cells.". J. Cell. Biochem. 93 (2): 398–408. 2005. doi:10.1002/jcb.20163. PMID 15368365.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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