Biology:NAT10

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

N-acetyltransferase 10 is an enzyme that in humans is encoded by the NAT10 gene.[1][2] NAT10 moderates the formation of N4-acetylcytidine RNA modifications on tRNA, rRNA, and mRNA.[3][4][5]

References

  1. "Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT". Biochemical and Biophysical Research Communications 311 (2): 506–13. Nov 2003. doi:10.1016/j.bbrc.2003.09.235. PMID 14592445. 
  2. "Entrez Gene: NAT10 N-acetyltransferase 10". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=55226. 
  3. Jin, Gehui; Xu, Mingqing; Zou, Mengsha; Duan, Shiwei (June 2020). "The Processing, Gene Regulation, Biological Functions, and Clinical Relevance of N4-Acetylcytidine on RNA: A Systematic Review". Molecular Therapy - Nucleic Acids 20: 13–24. doi:10.1016/j.omtn.2020.01.037. 
  4. Liu, Rucong; Wubulikasimu, Zibaguli; Cai, Runze; Meng, Fanyi; Cui, Qinghua; Zhou, Yuan; Li, Yang (8 September 2023). "NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells". Nucleic Acids Research 51 (16): 8514–8531. doi:10.1093/nar/gkad628. 
  5. Tardu, Mehmet; Jones, Joshua D.; Kennedy, Robert T.; Lin, Qishan; Koutmou, Kristin S. (19 July 2019). "Identification and Quantification of Modified Nucleosides in Saccharomyces cerevisiae mRNAs". ACS Chemical Biology 14 (7): 1403–1409. doi:10.1021/acschembio.9b00369. 

Further reading