Biology:NBR1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene. One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.

Interactions

NBR1 has been shown to interact with FEZ1.

Further reading

• Miki Y; Swensen J; Shattuck-Eidens D et al. (1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science 266 (5182): 66–71. doi:10.1126/science.7545954. PMID 7545954. Bibcode: 1994Sci...266...66M. 
• Harshman K; Bell R; Rosenthal J et al. (1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259–1266. doi:10.1093/hmg/4.8.1259. PMID 7581362. 
• Nomura N; Nagase T; Miyajima N et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–229. doi:10.1093/dnares/1.5.223. PMID 7584044. 
• Brown MA; Nicolai H; Xu CF et al. (1995). "Regulation of BRCA1". Nature 372 (6508): 733. doi:10.1038/372733a0. PMID 7997258. Bibcode: 1994Natur.372..733B. 
• Brown MA; Xu CF; Nicolai H et al. (1996). "The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21". Oncogene 12 (12): 2507–13. PMID 8700509. 
• "Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes". Gene 262 (1–2): 89–98. 2001. doi:10.1016/S0378-1119(00)00549-7. PMID 11179671. 
• Whitehouse C; Chambers J; Howe K et al. (2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. PMID 11856312. 
• Wistow G; Bernstein SL; Ray S et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412. 
• Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• Lamark T; Perander M; Outzen H et al. (2003). "Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins". J. Biol. Chem. 278 (36): 34568–34581. doi:10.1074/jbc.M303221200. PMID 12813044. 
• Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMID 15489334. 
• Lange S; Xiang F; Yakovenko A et al. (2005). "The kinase domain of titin controls muscle gene expression and protein turnover". Science 308 (5728): 1599–1603. doi:10.1126/science.1110463. PMID 15802564. Bibcode: 2005Sci...308.1599L. 
• Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.