Biology:NEIL2
From HandWiki
Short description: Gene of the species Homo sapiens
 Generic protein structure example |
Endonuclease VIII-like 2 is an enzyme that in humans is encoded by the NEIL2 gene.[1][2][3]
NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002)[supplied by OMIM][3]
References
- ↑ "Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions". J Biol Chem 277 (34): 30417–20. Aug 2002. doi:10.1074/jbc.C200355200. PMID 12097317.
- ↑ "Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress". J Biol Chem 282 (39): 28474–84. Sep 2007. doi:10.1074/jbc.M704672200. PMID 17686777.
- ↑ 3.0 3.1 "Entrez Gene: NEIL2 nei like 2 (E. coli)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=252969.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue.". J. Biol. Chem. 277 (44): 42205–13. 2003. doi:10.1074/jbc.M206884200. PMID 12200441.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII.". DNA Repair (Amst.) 1 (7): 517–29. 2003. doi:10.1016/S1568-7864(02)00036-8. PMID 12509226.
- "Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2.". J. Biol. Chem. 278 (50): 49679–84. 2004. doi:10.1074/jbc.M308658200. PMID 14522990.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions.". J. Biol. Chem. 279 (14): 14464–71. 2004. doi:10.1074/jbc.M400393200. PMID 14734554.
- "Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity.". Nucleic Acids Res. 32 (10): 3033–9. 2004. doi:10.1093/nar/gkh632. PMID 15175427.
- "Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein.". J. Biol. Chem. 279 (45): 47132–8. 2004. doi:10.1074/jbc.M406224200. PMID 15339932.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. 2006. doi:10.1093/nar/gkj139. PMID 16381901.
- "NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells.". DNA Repair (Amst.) 5 (12): 1439–48. 2007. doi:10.1016/j.dnarep.2006.07.003. PMID 16982218.
- "Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition.". BMC Cancer 6: 243. 2006. doi:10.1186/1471-2407-6-243. PMID 17029639.
- "Damage specificity of human DNA glycosylases for oxidative pyrimidine lesions.". Nucleic Acids Symp Ser (Oxf) 48 (48): 175–6. 2007. doi:10.1093/nass/48.1.175. PMID 17150535.
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