Biology:NKIRAS2
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NF-κB inhibitor interacting Ras-like 2 is a protein that in humans is encoded by the NKIRAS2 gene.[1]
Model organisms
| Characteristic | Phenotype |
|---|---|
| Homozygote viability | Normal |
| Fertility | Normal |
| Body weight | Normal |
| Anxiety | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Hot plate | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Body temperature | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology | Normal |
| Peripheral blood lymphocytes | Normal |
| Micronucleus test | Normal |
| Heart weight | Normal |
| Salmonella infection | Normal[2] |
| All tests and analysis from[3] |
Model organisms have been used in the study of NKIRAS2 function. A conditional knockout mouse line, called Nkiras2tm1a(EUCOMM)Wtsi[4][5] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[6][7][8]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[3][9] Twenty one tests were carried out, but no significant abnormalities were observed.[3]
References
- ↑ "Entrez Gene: NFKB inhibitor interacting Ras-like 2". https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=28511. Retrieved 2011-08-30.
- ↑ "Salmonella infection data for Nkiras2". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MATD/salmonella-challenge/.
- ↑ 3.0 3.1 3.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
- ↑ "International Knockout Mouse Consortium". http://www.knockoutmouse.org/martsearch/search?query=Nkiras2.
- ↑ "Mouse Genome Informatics". http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4432279.
- ↑ "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. Jun 2011. doi:10.1038/nature10163. PMID 21677750.
- ↑ "Mouse library set to be knockout". Nature 474 (7351): 262–3. Jun 2011. doi:10.1038/474262a. PMID 21677718.
- ↑ "A mouse for all reasons". Cell 128 (1): 9–13. Jan 2007. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ "The mouse genetics toolkit: revealing function and mechanism". Genome Biology 12 (6): 224. 2011. doi:10.1186/gb-2011-12-6-224. PMID 21722353.
Further reading
- "KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA". The Journal of Biological Chemistry 285 (40): 30622–33. Oct 2010. doi:10.1074/jbc.M110.117028. PMID 20639196.
- "A subclass of Ras proteins that regulate the degradation of IkappaB". Science 287 (5454): 869–73. Feb 2000. doi:10.1126/science.287.5454.869. PMID 10657303. Bibcode: 2000Sci...287..869F.
- "Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis". Annals of the Rheumatic Diseases 68 (4): 579–83. Apr 2009. doi:10.1136/ard.2007.087304. PMID 18434448.
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