Biology:NLGN4X
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Neuroligin-4, X-linked is a protein that in humans is encoded by the NLGN4X gene.[1][2]
In the human brain, the synaptic protein NLGN4 is primarily expressed in the cerebral cortex.[3]
This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Two transcript variants encoding the same protein have been identified for this gene.[2]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 6 (5): 337–45. October 1999. doi:10.1093/dnares/6.5.337. PMID 10574462.
- ↑ 2.0 2.1 "Entrez Gene: NLGN4X neuroligin 4, X-linked". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57502.
- ↑ "Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons". Neuron 103 (4): 617–626.e6. June 2019. doi:10.1016/j.neuron.2019.05.043. PMID 31257103.
Further reading
- "Synapse formation: if it looks like a duck and quacks like a duck". Current Biology 10 (17): R620-3. September 2000. doi:10.1016/S0960-9822(00)00663-1. PMID 10996085.
- "Binding of neuroligins to PSD-95". Science 277 (5331): 1511–5. September 1997. doi:10.1126/science.277.5331.1511. PMID 9278515.
- "Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression". The Biochemical Journal 356 (Pt 2): 581–8. June 2001. doi:10.1042/0264-6021:3560581. PMID 11368788.
- "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism". Nature Genetics 34 (1): 27–9. May 2003. doi:10.1038/ng1136. PMID 12669065.
- "X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family". American Journal of Human Genetics 74 (3): 552–7. March 2004. doi:10.1086/382137. PMID 14963808.
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science 13 (10): 2819–24. October 2004. doi:10.1110/ps.04682504. PMID 15340161.
- "Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients". Molecular Psychiatry 10 (4): 329–32. April 2005. doi:10.1038/sj.mp.4001629. PMID 15622415.
- "Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 141B (3): 220–1. April 2006. doi:10.1002/ajmg.b.30287. PMID 16508939.
- "Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism". Journal of Medical Genetics 43 (5): e21. May 2006. doi:10.1136/jmg.2005.036897. PMID 16648374.
- "Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations". Biochemical and Biophysical Research Communications 355 (1): 41–6. March 2007. doi:10.1016/j.bbrc.2007.01.127. PMID 17292328.
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