Biology:NUF2
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Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2 gene.[1][2][3]
This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation.
The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.[3]
References
- ↑ "The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation". J Cell Biol 152 (2): 349–60. Mar 2001. doi:10.1083/jcb.152.2.349. PMID 11266451.
- ↑ "A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint". Chromosoma 110 (5): 322–34. Oct 2001. doi:10.1007/s004120100153. PMID 11685532.
- ↑ 3.0 3.1 "Entrez Gene: NUF2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83540.
Further reading
- "hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells.". J. Cell Biol. 159 (4): 549–55. 2003. doi:10.1083/jcb.200208159. PMID 12438418.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model.". Mol. Cell. Proteomics 3 (1): 93–104. 2004. doi:10.1074/mcp.M300072-MCP200. PMID 14602875.
- "Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores.". Curr. Biol. 13 (23): 2103–9. 2004. doi:10.1016/j.cub.2003.10.056. PMID 14654001.
- "Identification of two novel components of the human NDC80 kinetochore complex.". J. Biol. Chem. 279 (13): 13076–85. 2004. doi:10.1074/jbc.M310224200. PMID 14699129.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo.". Curr. Biol. 14 (7): 611–7. 2004. doi:10.1016/j.cub.2004.03.031. PMID 15062103.
- "Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1.". Chromosoma 113 (1): 1–15. 2005. doi:10.1007/s00412-004-0288-2. PMID 15235793.
- "Timing and checkpoints in the regulation of mitotic progression.". Dev. Cell 7 (1): 45–60. 2004. doi:10.1016/j.devcel.2004.06.006. PMID 15239953.
- "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.". Genes Dev. 18 (18): 2255–68. 2004. doi:10.1101/gad.1234104. PMID 15371340.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites.". Mol. Biol. Cell 16 (2): 519–31. 2005. doi:10.1091/mbc.E04-09-0852. PMID 15548592.
- "Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore.". J. Biol. Chem. 280 (32): 29088–95. 2005. doi:10.1074/jbc.M504070200. PMID 15961401.
- "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N.
- "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- "Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment.". J. Biol. Chem. 282 (29): 21415–24. 2007. doi:10.1074/jbc.M609026200. PMID 17535814.
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