Biology:Neurotrophin-4

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Neurotrophin-4 (NT-4), also known as neurotrophin-5 (NT-5), is a protein that in humans is encoded by the NTF4 gene. It is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase. NT-4 was first discovered and isolated from xenopus and viper in the year 1991 by Finn Hallbook et.al

See also

• Tropomyosin receptor kinase B § Agonists

Further reading

• "Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development". Developmental Dynamics 239 (4): 1211–1219. April 2010. doi:10.1002/dvdy.22252. PMID 20175187. 
• "Identification of a novel mutation in the NTF4 gene that causes primary open-angle glaucoma in a Chinese population". Molecular Vision 16: 1640–1645. August 2010. PMID 20806036. 
• "Neurotrophins and their receptors stimulate melanoma cell proliferation and migration". The Journal of Investigative Dermatology 128 (8): 2031–2040. August 2008. doi:10.1038/jid.2008.21. PMID 18305571. 
• "Tyrosine kinase B receptor and its activated neurotrophins in ovaries from human fetuses and adults". Molecular Human Reproduction 12 (6): 357–365. June 2006. doi:10.1093/molehr/gal033. PMID 16648150. 
• "Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder". Biological Psychiatry 63 (10): 935–945. May 2008. doi:10.1016/j.biopsych.2007.11.004. PMID 18179783. 
• "Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway". The Journal of Neuroscience 25 (26): 6156–6166. June 2005. doi:10.1523/JNEUROSCI.1017-05.2005. PMID 15987945. 
• "Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma". American Journal of Human Genetics 85 (4): 447–456. October 2009. doi:10.1016/j.ajhg.2009.08.016. PMID 19765683. 
• "Neurotrophin-4: the odd one out in the neurotrophin family". Neurochemical Research 21 (7): 787–793. July 1996. doi:10.1007/BF02532301. PMID 8873083. 
• "A novel function of differentiation revealed by cDNA microarray profiling of p75NTR-regulated gene expression". Differentiation; Research in Biological Diversity 73 (8): 385–396. October 2005. doi:10.1111/j.1432-0436.2005.00040.x. PMID 16316409. 
• "No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma". American Journal of Human Genetics 86 (3): 498–9; author reply 500. March 2010. doi:10.1016/j.ajhg.2009.11.018. PMID 20215012. 
• "The conservation of neurotrophic factors during vertebrate evolution". Comparative Biochemistry and Physiology. Pharmacology, Toxicology and Endocrinology 108 (1): 1–10. May 1994. doi:10.1016/1367-8280(94)90082-5. PMID 8061955. https://opus.bibliothek.uni-wuerzburg.de/files/5954/Schartl66.pdf. 
• "Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease". Journal of Psychiatric Research 44 (13): 834–840. October 2010. doi:10.1016/j.jpsychires.2010.01.009. PMID 20219210. 
• "Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome". Autism Research 2 (3): 157–177. June 2009. doi:10.1002/aur.80. PMID 19598235. 
• "Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells". Journal of Periodontology 79 (11): 2182–2189. November 2008. doi:10.1902/jop.2008.070402. PMID 18980528. 
• "Variations in NTF4, VAV2, and VAV3 genes are not involved with primary open-angle and primary angle-closure glaucomas in an indian population". Investigative Ophthalmology & Visual Science 51 (10): 4937–4941. October 2010. doi:10.1167/iovs.10-5553. PMID 20463313. 
• "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 150B (6): 808–816. September 2009. doi:10.1002/ajmg.b.30902. PMID 19086053. 
• "Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders". Human Molecular Genetics 17 (9): 1234–1244. May 2008. doi:10.1093/hmg/ddn013. PMID 18203754. 
• "Increased serum neurotrophin-4/5 levels in bipolar disorder". Journal of Psychiatric Research 43 (7): 721–723. April 2009. doi:10.1016/j.jpsychires.2008.10.005. PMID 19081579. 
• "Neurotrophin effects on intracellular Ca2+ and force in airway smooth muscle". American Journal of Physiology. Lung Cellular and Molecular Physiology 291 (3): L447–L456. September 2006. doi:10.1152/ajplung.00501.2005. PMID 16648236. 

External links

• neurotrophin+4 at the US National Library of Medicine Medical Subject Headings (MeSH)
• neurotrophin+5 at the US National Library of Medicine Medical Subject Headings (MeSH)