Biology:Nitrate reductase (quinone)

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Nitrate reductase (quinone) (EC 1.7.5.1, nitrate reductase A, nitrate reductase Z, quinol/nitrate oxidoreductase, quinol-nitrate oxidoreductase, quinol:nitrate oxidoreductase, NarA, NarZ, NarGHI) is an enzyme with systematic name nitrite:quinone oxidoreductase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

nitrate + a quinol [math]\displaystyle{ \rightleftharpoons }[/math] nitrite + a quinone + H2O

This is a membrane-bound enzyme which supports [anaerobic respiration] on nitrate.

References

  1. "The role of a novel cytochrome b-containing nitrate reductase and quinone in the in vitro reconstruction of formate-nitrate reductase activity of E. coli". Biochemical and Biophysical Research Communications 61 (4): 1234–41. December 1974. doi:10.1016/s0006-291x(74)80416-x. PMID 4616697. 
  2. "Insights into the respiratory electron transfer pathway from the structure of nitrate reductase A". Nature Structural Biology 10 (9): 681–7. September 2003. doi:10.1038/nsb969. PMID 12910261. 
  3. "High-stability semiquinone intermediate in nitrate reductase A (NarGHI) from Escherichia coli is located in a quinol oxidation site close to heme bD". Biochemistry 46 (18): 5323–9. May 2007. doi:10.1021/bi700074y. PMID 17439244. 
  4. "Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A". The Journal of Biological Chemistry 280 (15): 14836–43. April 2005. doi:10.1074/jbc.M410457200. PMID 15615728. 
  5. "Nitrate reductases in Escherichia coli". Antonie van Leeuwenhoek 66 (1-3): 47–56. 1994. doi:10.1007/bf00871632. PMID 7747940. 
  6. "EPR and redox characterization of iron-sulfur centers in nitrate reductases A and Z from Escherichia coli. Evidence for a high-potential and a low-potential class and their relevance in the electron-transfer mechanism". European Journal of Biochemistry 207 (1): 61–8. July 1992. doi:10.1111/j.1432-1033.1992.tb17020.x. PMID 1321049. 
  7. "Purification and further characterization of the second nitrate reductase of Escherichia coli K12". European Journal of Biochemistry 188 (3): 679–87. March 1990. doi:10.1111/j.1432-1033.1990.tb15450.x. PMID 2139607. 

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