Biology:Nitroquinoline-N-oxide reductase

From HandWiki
Short description: Class of enzymes
nitroquinoline-N-oxide reductase
Identifiers
EC number1.7.1.9
CAS number37256-35-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a nitroquinoline-N-oxide reductase (EC 1.7.1.9) is an enzyme that catalyzes the chemical reaction

4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+

The 4 substrates of this enzyme are 4-hydroxyaminoquinoline N-oxide, NAD+, NADP+, and H2O, whereas its 4 products are 4-nitroquinoline N-oxide, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase. Other names in common use include 4-nitroquinoline 1-oxide reductase, 4NQO reductase, and NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase.

References

  • Toriyama N (1965). "[Metabolism of quinoline derivatives. On the reducing enzyme of 4-nitroquinoline-N-oxide]". Nichidai Igaku Zasshi 24: 423–432. 
  • "Nitroreductases and glutathione transferases that act on 4-nitroquinoline 1-oxide and their differential induction by butylated hydroxyanisole in mice". Cancer Res. 52 (1): 58–63. 1992. PMID 1370076.