Biology:OAZ2
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Ornithine decarboxylase antizyme 2 is an enzyme that in humans is encoded by the OAZ2 gene.[1][2][3]
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase but does not accelerate its degradation.[3]
References
- ↑ "A second mammalian antizyme: conservation of programmed ribosomal frameshifting". Genomics 52 (2): 119–29. Dec 1998. doi:10.1006/geno.1998.5434. PMID 9782076.
- ↑ "Structure of human ornithine decarboxylase antizyme 2 gene". Gene 232 (2): 165–71. Jul 1999. doi:10.1016/S0378-1119(99)00128-6. PMID 10352227.
- ↑ 3.0 3.1 "Entrez Gene: OAZ2 ornithine decarboxylase antizyme 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4947.
Further reading
- Coffino P (2000). "Polyamines in spermiogenesis: not now, darling.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4421–3. doi:10.1073/pnas.97.9.4421. PMID 10781034. Bibcode: 2000PNAS...97.4421C.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- "Regulation of all members of the antizyme family by antizyme inhibitor.". Biochem. J. 385 (Pt 1): 21–8. 2005. doi:10.1042/BJ20040547. PMID 15355308.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase.". J. Biol. Chem. 277 (48): 45957–61. 2003. doi:10.1074/jbc.M206799200. PMID 12359729.
- "Polyamines regulate both transcription and translation of the gene encoding ornithine decarboxylase antizyme in mouse.". Eur. J. Biochem. 250 (2): 223–31. 1998. doi:10.1111/j.1432-1033.1997.0223a.x. PMID 9428668.
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
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