Biology:OR51E2
 Generic protein structure example |
Olfactory receptor 51E2 is a protein that in humans is encoded by the OR51E2 gene.[1][2]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[2]
Ligands
OR51E2 is a relatively narrowly tuned olfactory receptor, meaning it responds only to a relatively small set of related odorants.[3]
OR51E2 responds to short-chain fatty acids,[4] including in particular propionic acid.[3]
See also
References
- ↑ "PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer". Cancer Res 60 (23): 6568–72. Dec 2000. PMID 11118034.
- ↑ 2.0 2.1 "Entrez Gene: OR51E2 olfactory receptor, family 51, subfamily E, member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81285.
- ↑ 3.0 3.1 "Odor coding by a Mammalian receptor repertoire". Science Signaling 2 (60): ra9. March 2009. doi:10.1126/scisignal.2000016. PMID 19261596.
- ↑ "Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation". Proceedings of the National Academy of Sciences of the United States of America 110 (11): 4410–5. March 2013. doi:10.1073/pnas.1215927110. PMID 23401498. Bibcode: 2013PNAS..110.4410P.
Further reading
- "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature 377 (6547 Suppl): 3–174. 1995. PMID 7566098. http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf.
- "Identification of a prostate-specific G-protein coupled receptor in prostate cancer". Oncogene 20 (41): 5903–7. 2001. doi:10.1038/sj.onc.1204803. PMID 11593396.
- "Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species". Gene 278 (1–2): 41–51. 2002. doi:10.1016/S0378-1119(01)00709-0. PMID 11707321.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. 2004. doi:10.1073/pnas.0307882100. PMID 14983052. Bibcode: 2004PNAS..101.2584M.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers". Int. J. Cancer 113 (5): 811–8. 2005. doi:10.1002/ijc.20635. PMID 15499628.
- "Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors". J. Cell. Biochem. 96 (5): 1034–48. 2006. doi:10.1002/jcb.20600. PMID 16149059.
- "Quantitative expression profile of PSGR in prostate cancer". Prostate Cancer Prostatic Dis. 9 (1): 56–61. 2006. doi:10.1038/sj.pcan.4500836. PMID 16231015.
- "The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase". Prostate 66 (8): 847–57. 2006. doi:10.1002/pros.20389. PMID 16491480.
External links
- OR51E2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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