Biology:ORM1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene.[1]
This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.[1]
Interactions
ORM1 has been shown to interact with Plasminogen activator inhibitor-1.[2]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: ORM1 orosomucoid 1". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5004.
- ↑ Boncela, J; Papiewska I; Fijalkowska I; Walkowiak B; Cierniewski C S (Sep 2001). "Acute phase protein alpha 1-acid glycoprotein interacts with plasminogen activator inhibitor type 1 and stabilizes its inhibitory activity". J. Biol. Chem. (United States) 276 (38): 35305–11. doi:10.1074/jbc.M104028200. ISSN 0021-9258. PMID 11418606.
Further reading
- "Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein.". Biochem. J. 283 (1): 105–12. 1992. doi:10.1042/bj2830105. PMID 1567356.
- "Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes.". Nucleic Acids Res. 13 (11): 3941–52. 1985. doi:10.1093/nar/13.11.3941. PMID 2409529.
- "Synthesis of alpha 1-acid glycoprotein by the human prostate.". Prostate 15 (3): 251–8. 1989. doi:10.1002/pros.2990150305. PMID 2479939.
- "Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter?". Hum. Genet. 82 (1): 17–9. 1989. doi:10.1007/bf00288264. PMID 2541064.
- "Structure and expression of the genes coding for human alpha 1-acid glycoprotein.". EMBO J. 6 (8): 2289–96. 1987. doi:10.1002/j.1460-2075.1987.tb02503.x. PMID 2822385.
- "Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene.". Gene 66 (1): 97–106. 1988. doi:10.1016/0378-1119(88)90228-4. PMID 2970990.
- "Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice.". Genes Dev. 2 (2): 259–66. 1988. doi:10.1101/gad.2.2.259. PMID 3360326.
- "Mapping through somatic cell hybrids and cDNA probes of protein C to chromosome 2, factor X to chromosome 13, and alpha 1-acid glycoprotein to chromosome 9.". Hum. Genet. 74 (1): 30–3. 1986. doi:10.1007/BF00278781. PMID 3463531.
- "Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA.". Gene 44 (1): 127–31. 1986. doi:10.1016/0378-1119(86)90051-X. PMID 3770479.
- "Interaction between human serum albumin and alpha 1-acid glycoprotein in the binding of lidocaine to purified protein fractions and sera.". J. Pharmacol. Exp. Ther. 239 (3): 754–9. 1987. PMID 3795040.
- "Isolation and partial characterization of the cyanogen bromide fragments of 1 -acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment.". Biochemistry 11 (20): 3817–29. 1972. doi:10.1021/bi00770a022. PMID 4561179.
- "The disulfide bonds of alpha1-acid glycoprotein.". Biochemistry 13 (13): 2694–7. 1974. doi:10.1021/bi00710a006. PMID 4603214.
- "Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins.". Biochemistry 12 (14): 2711–24. 1973. doi:10.1021/bi00738a026. PMID 4711474.
- "Plasma proteins in human cortical bone: enrichment of alpha 2 HS-glycoprotein, alpha 1 acid-glycoprotein, and IgE.". Calcif. Tissue Int. 34 (3): 229–31. 1982. doi:10.1007/BF02411242. PMID 6809283.
- "alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans.". Glycoconj. J. 12 (1): 7–16. 1995. doi:10.1007/BF00731863. PMID 7795416.
- "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199–207. 1994. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
- "Alpha 1-acid glycoprotein expression in human leukocytes: possible correlation between alpha 1-acid glycoprotein and inflammatory cytokines in rheumatoid arthritis.". Inflammation 17 (1): 33–45. 1993. doi:10.1007/BF00916390. PMID 8432561. https://deepblue.lib.umich.edu/bitstream/2027.42/44509/1/10753_2004_Article_BF00916390.pdf.
- "Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S.". Hum. Genet. 99 (3): 393–8. 1997. doi:10.1007/s004390050378. PMID 9050929.
- "Melatonin high-affinity binding to alpha-1-acid glycoprotein in human serum.". Pharmacology 54 (5): 271–5. 1997. doi:10.1159/000139495. PMID 9380773.
- "The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2.". Biochem. Biophys. Res. Commun. 276 (2): 779–84. 2000. doi:10.1006/bbrc.2000.3522. PMID 11027547.
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