Biology:OSBPL1A
From HandWiki
 Generic protein structure example |
Oxysterol-binding protein-related protein 1 is a protein that in humans is encoded by the OSBPL1A gene.[1][2][3]
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.[3]
References
- ↑ "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport". J Biol Chem 276 (21): 18407–14. May 2001. doi:10.1074/jbc.M101204200. PMID 11279184.
- ↑ "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". J Lipid Res 40 (12): 2204–11. Feb 2000. doi:10.1016/S0022-2275(20)32095-2. PMID 10588946.
- ↑ 3.0 3.1 "Entrez Gene: OSBPL1A oxysterol binding protein-like 1A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114876.
Further reading
- "The OSBP-related protein family in humans.". J. Lipid Res. 42 (8): 1203–13. 2001. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
- "A family of 12 human genes containing oxysterol-binding domains.". Genomics 78 (3): 185–96. 2002. doi:10.1006/geno.2001.6663. PMID 11735225. https://zenodo.org/record/1229818.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct.". Mol. Biol. Cell 14 (3): 903–15. 2004. doi:10.1091/mbc.E02-08-0459. PMID 12631712.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments.". Mol. Biol. Cell 16 (12): 5480–92. 2006. doi:10.1091/mbc.E05-03-0189. PMID 16176980.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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