Biology:OVGP1
 Generic protein structure example |
Oviduct-specific glycoprotein also known as oviductal glycoprotein (OGP) or estrogen-dependent oviduct protein (EGP) or mucin-9 (MUC9) is a protein that in humans is encoded by the OVGP1 gene.[1][2][3]
Function
Oviduct-specific glycoprotein is a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoon acrosomal regions.[3] Beyond the oviduct, OVGP1 is detected in the mouse ovary, testis and epididymis suggesting its roles beyond fertilization. It is not detected in the mouse uterus, cervix, vagina, breast, seminal vesicles and prostate gland [4] OVGP1 is expressed by the surface epithelium of the endometrium at the time of embryo implantation in the mouse. It is required for maintain the receptivity phenotype and trophoblast adhesion, OVGP1 mRNA levels are reduced in endometrium of women with recurrent implantation failure [5]
References
- ↑ "Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein". Biol Reprod 51 (4): 685–94. Feb 1995. doi:10.1095/biolreprod51.4.685. PMID 7819450.
- ↑ "Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9)". Fertil Steril 68 (4): 702–8. Nov 1997. doi:10.1016/S0015-0282(97)00317-8. PMID 9341614.
- ↑ 3.0 3.1 "Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5016.
- ↑ Laheri, Saniya; Modi, Deepak; Bhatt, Purvi (Mar 2017). "Extra-oviductal expression of oviductal glycoprotein 1 in mouse: Detection in testis, epididymis and ovary.". Journal of Biosciences 42 (1): 69–80. doi:10.1007/s12038-016-9657-2. PMID 28229966. https://www.ias.ac.in/article/fulltext/jbsc/042/01/0069-0080. Retrieved 16 July 2018.
- ↑ Laheri, Saniya; Ashary, Nancy; Bhatt, Purvi; Modi, Deepak (2018). "Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion". Journal of Assisted Reproduction and Genetics 35 (8): 1419–1429. doi:10.1007/s10815-018-1231-4. PMID 29968069.
- Laheri, Saniya; Ashary, Nancy; Bhatt, Purvi; Modi, Deepak (2018). "Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion". Journal of Assisted Reproduction and Genetics 35 (8): 1419–1429. doi:10.1007/s10815-018-1231-4. PMID 29968069.
Further reading
- "The in vitro synthesis and release of proteins by the human oviduct". Endocrinology 122 (4): 1639–45. 1988. doi:10.1210/endo-122-4-1639. PMID 3278893.
- "Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins". J. Dent. Res. 76 (3): 734–43. 1997. doi:10.1177/00220345970760030501. PMID 9109822.
- "Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system". J. Dent. Res. 79 (2): 732–9. 2000. doi:10.1177/00220345000790020601. PMID 10728974.
- "Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter". Mol. Hum. Reprod. 8 (2): 167–75. 2002. doi:10.1093/molehr/8.2.167. PMID 11818519.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- "Variable expression of oviductin mRNA at different stages of human reproductive cycle". J. Assist. Reprod. Genet. 19 (12): 569–76. 2003. doi:10.1023/A:1021263132176. PMID 12503889.
- "Homology of primate DNA fragments for estrous-associated oviductal glycoprotein". Hereditas 139 (1): 75–9. 2004. doi:10.1111/j.1601-5223.2003.01640.x. PMID 14641477.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Woo MM; Alkushi A; Verhage HG et al. (2005). "Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer". Clin. Cancer Res. 10 (23): 7958–64. doi:10.1158/1078-0432.CCR-04-1261. PMID 15585630.
- Ling L; Lee YL; Lee KF et al. (2006). "Expression of human oviductin in an immortalized human oviductal cell line". Fertil. Steril. 84 Suppl 2: 1095–103. doi:10.1016/j.fertnstert.2005.06.006. PMID 16209999.
- "Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9". Mol. Hum. Reprod. 12 (4): 275–82. 2006. doi:10.1093/molehr/gal028. PMID 16567366.
- Gregory SG; Barlow KF; McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
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