Biology:Omzotirome
From HandWiki
Omzotirome (INN), formerly codenamed TRC-150094, is a thyromimetic drug which acts as a metabolic modulator which restores metabolic flexibility. It has been shown to improve insulin resistance and hyperglycemia, and is in Phase III human clinical trials for the treatment of Cardiometabolic-Based Chronic Disease (CMBCD) by improving dysglycemia, dyslipidemia and hypertension.[1][2][3][4][5]
References
- ↑ "TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet". FASEB Journal 24 (9): 3451–61. September 2010. doi:10.1096/fj.10-157115. PMID 20453112.
- ↑ "Metabolic effects of the iodothyronine functional analogue TRC150094 on the liver and skeletal muscle of high-fat diet fed overweight rats: an integrated proteomic study". Molecular BioSystems 8 (7): 1987–2000. July 2012. doi:10.1039/c2mb25055a. PMID 22543897.
- ↑ "The effect of a diiodothyronine mimetic on insulin sensitivity in male cardiometabolic patients: a double-blind randomized controlled trial". PLOS ONE 9 (2). 2014. doi:10.1371/journal.pone.0086890. PMID 24586256. Bibcode: 2014PLoSO...986890V.
- ↑ "Thyroid hormone analogues and derivatives: Actions in fatty liver". World Journal of Hepatology 6 (3): 114–29. March 2014. doi:10.4254/wjh.v6.i3.114. PMID 24672641.
- ↑ Clinical trial number NCT03254446 for "Safety and Efficacy Study of TRC150094 to Improve the CV Risk in Subjects With Diabetes, Dyslipidemia and Hypertension. Torrent Pharmaceuticals Ltd." at ClinicalTrials.gov
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