Biology:PAG1
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Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 gene.[1][2]
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.[2]
Interactions
PAG1 has been shown to interact with FYN,[1] C-src tyrosine kinase,[1] Sodium-hydrogen antiporter 3 regulator 1[3] and Abl gene.[4]
References
- ↑ 1.0 1.1 1.2 "Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation". The Journal of Experimental Medicine 191 (9): 1591–604. May 2000. doi:10.1084/jem.191.9.1591. PMID 10790433.
- ↑ 2.0 2.1 "Entrez Gene: PAG1 phosphoprotein associated with glycosphingolipid microdomains 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55824.
- ↑ "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Letters 507 (2): 133–6. October 2001. doi:10.1016/S0014-5793(01)02955-6. PMID 11684085.
- ↑ "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity". Genes & Development 11 (19): 2456–67. October 1997. doi:10.1101/gad.11.19.2456. PMID 9334312.
Further reading
- "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity". Genes & Development 11 (19): 2456–67. October 1997. doi:10.1101/gad.11.19.2456. PMID 9334312.
- "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Letters 507 (2): 133–6. October 2001. doi:10.1016/S0014-5793(01)02955-6. PMID 11684085.
- "Transmembrane adaptor molecules: a new category of lymphoid-cell markers". Blood 107 (1): 213–21. January 2006. doi:10.1182/blood-2005-06-2273. PMID 16160011.
- "Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation". Oncogene 25 (40): 5495–506. September 2006. doi:10.1038/sj.onc.1209554. PMID 16636672.
- "Expression and purification of human PAG, a transmembrane adapter protein using an insect cell expression system and its structure basis". The Protein Journal 25 (4): 295–9. June 2006. doi:10.1007/s10930-006-9015-6. PMID 16947079.
- "Germline gain-of-function mutations in SOS1 cause Noonan syndrome". Nature Genetics 39 (1): 70–4. January 2007. doi:10.1038/ng1926. PMID 17143285.
- "A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation". Blood 110 (2): 596–615. July 2007. doi:10.1182/blood-2006-07-038752. PMID 17389760.
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