Biology:PCBP3
From HandWiki
Short description: Gene of the species Homo sapiens
 Generic protein structure example |
Poly(rC)-binding protein 3 is a protein that in humans is encoded by the PCBP3 gene.[1][2]
This gene encodes a member of the KH domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple polyadenylation sites exist for this gene.[2]
References
- ↑ "Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins". Genomics 67 (3): 301–16. Sep 2000. doi:10.1006/geno.2000.6244. PMID 10936052.
- ↑ 2.0 2.1 "Entrez Gene: PCBP3 poly(rC) binding protein 3". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=54039.
Further reading
- "The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms.". RNA 8 (3): 265–78. 2002. doi:10.1017/S1355838202024627. PMID 12003487.
- "Identification of two KH domain proteins in the alpha-globin mRNP stability complex.". EMBO J. 14 (17): 4357–64. 1995. doi:10.1002/j.1460-2075.1995.tb00110.x. PMID 7556077.
- "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. 2000. doi:10.1038/35012518. PMID 10830953. Bibcode: 2000Natur.405..311H.
- "Targeting a KH-domain protein with RNA decoys.". RNA 8 (9): 1160–73. 2002. doi:10.1017/S135583820202808X. PMID 12358435.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins.". Mol. Cell. Biol. 23 (23): 8405–15. 2003. doi:10.1128/MCB.23.23.8405-8415.2003. PMID 14612387.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.". BMC Genomics 7. 2006. doi:10.1186/1471-2164-7-155. PMID 16780588.
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