Biology:PDGFA
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Platelet-derived growth factor subunit A is a protein that in humans is encoded by the PDGFA gene.[1][2]
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.[3]
References
- ↑ "The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22". Cytogenet Cell Genet 60 (3–4): 206–7. Sep 1992. doi:10.1159/000133337. PMID 1505216.
- ↑ "Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes". Science 243 (4892): 800–4. Mar 1989. doi:10.1126/science.2536956. PMID 2536956. Bibcode: 1989Sci...243..800M. https://zenodo.org/record/1231010.
- ↑ "Entrez Gene: PDGFA platelet-derived growth factor alpha polypeptide". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5154.
Further reading
- "Vascular hamartoma and vascular tumours of orbit". Indian Journal of Ophthalmology 25 (1): 18–23. 1978. PMID 612586.
- "Expression cloning of a human dual-specificity phosphatase". Proc. Natl. Acad. Sci. U.S.A. 89 (24): 12170–4. 1993. doi:10.1073/pnas.89.24.12170. PMID 1281549.
- "The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1281–5. 1992. doi:10.1073/pnas.89.4.1281. PMID 1311092. Bibcode: 1992PNAS...89.1281R.
- "Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF". J. Biol. Chem. 267 (16): 11260–6. 1992. doi:10.1016/S0021-9258(19)49905-5. PMID 1317862.
- "Platelet-derived growth factor (PDGF) A-chain mRNA heterogeneity generated by the use of alternative promoters and alternative polyadenylation sites". Growth Factors 7 (3): 241–51. 1993. doi:10.3109/08977199209046928. PMID 1360804.
- "Modulation of transcription of the platelet-derived growth factor A-chain gene by a promoter region sensitive to S1 nuclease". J. Biol. Chem. 267 (24): 17022–31. 1992. doi:10.1016/S0021-9258(18)41887-X. PMID 1512241.
- "Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite". Genomics 13 (2): 257–63. 1992. doi:10.1016/0888-7543(92)90240-S. PMID 1612586.
- "Promoter region of the human platelet-derived growth factor A-chain gene". Proc. Natl. Acad. Sci. U.S.A. 88 (5): 1686–90. 1991. doi:10.1073/pnas.88.5.1686. PMID 1848007. Bibcode: 1991PNAS...88.1686T.
- "Expression of platelet-derived growth factor A-chain (PDGF-A) mRNA in lung tissue and cells. Complex regulation during remodeling". Chest 99 (3 Suppl): 52S–54S. 1991. doi:10.1378/chest.99.3_Supplement.52S. PMID 1997274.
- "Increased platelet-derived growth factor A-chain expression in human uterine smooth muscle cells during the physiologic hypertrophy of pregnancy". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2177–81. 1990. doi:10.1073/pnas.87.6.2177. PMID 2315311. Bibcode: 1990PNAS...87.2177M.
- "cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor". Proc. Natl. Acad. Sci. U.S.A. 86 (13): 4917–21. 1989. doi:10.1073/pnas.86.13.4917. PMID 2544881. Bibcode: 1989PNAS...86.4917C.
- "Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins". Mol. Cell. Biol. 8 (2): 571–7. 1988. doi:10.1128/MCB.8.2.571. PMID 2832727.
- "Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains". Science 241 (4871): 1346–9. 1988. doi:10.1126/science.2842868. PMID 2842868. Bibcode: 1988Sci...241.1346B. https://zenodo.org/record/1231155.
- "Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing". Proc. Natl. Acad. Sci. U.S.A. 85 (5): 1492–6. 1988. doi:10.1073/pnas.85.5.1492. PMID 3422746. Bibcode: 1988PNAS...85.1492B.
- "cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains". Nature 328 (6131): 619–21. 1987. doi:10.1038/328619a0. PMID 3614363.
- "Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain". Nature 328 (6131): 621–4. 1987. doi:10.1038/328621a0. PMID 3614364.
- "The long 3'-untranslated regions of the PDGF-A and -B mRNAs are only distantly related". FEBS Lett. 223 (2): 243–6. 1987. doi:10.1016/0014-5793(87)80297-1. PMID 3666150.
- "cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines". Nature 320 (6064): 695–9. 1986. doi:10.1038/320695a0. PMID 3754619. Bibcode: 1986Natur.320..695B.
- "Nucleotide sequence of the 5' region of the human platelet-derived growth factor A-chain gene". Hiroshima J. Med. Sci. 42 (1): 47–52. 1993. PMID 8486521.
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