Biology:PDS5B
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Sister chromatid cohesion protein PDS5 homolog B (PDS5B) is a protein that in humans is encoded by the PDS5B gene.[1][2][3] It is a regulatory subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. The core cohesin complex is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. PDS5 associates with WAPL to stimulate the release of cohesin from DNA but during DNA replication PDS5 promotes acetylation of SMC3 by ESCO1 and ESCO2.
References
- ↑ "Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13". Genomics 36 (1): 86–99. Feb 1997. doi:10.1006/geno.1996.0428. PMID 8812419.
- ↑ "Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus". J Steroid Biochem Mol Biol 68 (1–2): 41–50. May 1999. doi:10.1016/S0960-0760(98)00165-4. PMID 10215036.
- ↑ "Entrez Gene: APRIN androgen-induced proliferation inhibitor". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23047.
 |  |
