Biology:PEX5

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Peroxisomal targeting signal 1 receptor (PTS1R) is a protein that in humans is encoded by the PEX5 gene.[1]

PTS1R is a peroxisomal targeting sequence involved in the specific transport of molecules for oxidation inside the peroxisome. SKL binds to PTS1R in the cytosol followed by binding to the Pex14p receptor allowing importation of the peroxisomal protein through the pexsubunit transporter.

Diseases associated with dysfunctional PTS1R receptors include X-linked adrenoleukodystrophy and Zellweger syndrome.

Interactions

PEX5 has been shown to interact with PEX12,[2][3] PEX13[4][5] and PEX14.[3][5][6]

References

  1. "Entrez Gene: PEX5 Peroxisomal biogenesis factor 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5830. 
  2. "PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import". The Journal of Cell Biology 147 (4): 761–74. Nov 1999. doi:10.1083/jcb.147.4.761. PMID 10562279. 
  3. 3.0 3.1 "Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p". The Journal of Biological Chemistry 275 (33): 25700–10. Aug 2000. doi:10.1074/jbc.M003303200. PMID 10837480. 
  4. "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". The Journal of Cell Biology 135 (1): 85–95. Oct 1996. doi:10.1083/jcb.135.1.85. PMID 8858165. 
  5. 5.0 5.1 "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology 22 (6): 1639–55. Mar 2002. doi:10.1128/MCB.22.6.1639-1655.2002. PMID 11865044. 
  6. "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis". The Journal of Biological Chemistry 274 (18): 12593–604. Apr 1999. doi:10.1074/jbc.274.18.12593. PMID 10212238. 

Further reading

External links