Biology:PFDN4
From HandWiki
 Generic protein structure example |
Prefoldin subunit 4 is a protein that in humans is encoded by the PFDN4 gene.[1][2][3]
Function
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.[3]
References
- ↑ "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell 93 (5): 863–73. May 1998. doi:10.1016/s0092-8674(00)81446-4. PMID 9630229.
- ↑ "Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines". Acta Medica Okayama 50 (2): 73–7. Apr 1996. PMID 8744932.
- ↑ 3.0 3.1 "Control of ionic permeabilities in normal and ischemic heart". Circulation Research 38 (5 Suppl 1): I92–8. May 1976. PMID 5203. https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5203.
Further reading
- "Molecular chaperones in the cytosol: from nascent chain to folded protein". Science 295 (5561): 1852–8. Mar 2002. doi:10.1126/science.1068408. PMID 11884745.
- "Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins". The Journal of Cell Biology 145 (2): 265–77. Apr 1999. doi:10.1083/jcb.145.2.265. PMID 10209023.
- "A chaperone with a hydrophilic surface". Nature Structural Biology 6 (11): 990–1. Nov 1999. doi:10.1038/14870. PMID 10542082.
- "Comprehensive genome sequence analysis of a breast cancer amplicon". Genome Research 11 (6): 1034–42. Jun 2001. doi:10.1101/gr.gr1743r. PMID 11381030.
- "Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT". The EMBO Journal 21 (23): 6377–86. Dec 2002. doi:10.1093/emboj/cdf640. PMID 12456645.
- "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science 302 (5648): 1208–12. Nov 2003. doi:10.1126/science.1088401. PMID 14615539.
- "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". The Journal of Biological Chemistry 279 (6): 4196–203. Feb 2004. doi:10.1074/jbc.M306053200. PMID 14634002.
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