Biology:PHC2
 Generic protein structure example |
Polyhomeotic-like protein 2 is a protein that in humans is encoded by the PHC2 gene.[1][2][3]
Function
In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.[3]
Interactions
PHC2 has been shown to interact with MAPKAPK2,[4] PHC1,[1][5] BMI1[1] and MCRS1.[5]
References
- ↑ 1.0 1.1 1.2 "Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic". Molecular and Cellular Biology 17 (4): 2326–35. Apr 1997. doi:10.1128/mcb.17.4.2326. PMID 9121482.
- ↑ "Identification and characterisation of novel mammalian homologues of Drosophila polyhomeoticpermits new insights into relationships between members of the polyhomeotic family". Human Genetics 111 (4–5): 435–42. Oct 2002. doi:10.1007/s00439-002-0814-3. PMID 12384788.
- ↑ 3.0 3.1 "Entrez Gene: PHC2 polyhomeotic homolog 2 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1912.
- ↑ "P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity". FEBS Letters 564 (1–2): 205–11. Apr 2004. doi:10.1016/S0014-5793(04)00351-5. PMID 15094067.
- ↑ 5.0 5.1 "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
Further reading
- "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Molecular and Cellular Biology 17 (7): 4105–13. Jul 1997. doi:10.1128/mcb.17.7.4105. PMID 9199346.
- "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Molecular and Cellular Biochemistry 210 (1–2): 131–42. Jul 2000. doi:10.1023/A:1007177623283. PMID 10976766.
- "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Molecular and Cellular Biology 22 (17): 6070–8. Sep 2002. doi:10.1128/MCB.22.17.6070-6078.2002. PMID 12167701.
- "P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity". FEBS Letters 564 (1–2): 205–11. Apr 2004. doi:10.1016/S0014-5793(04)00351-5. PMID 15094067.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. Aug 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "Role of histone H2A ubiquitination in Polycomb silencing". Nature 431 (7010): 873–8. Oct 2004. doi:10.1038/nature02985. PMID 15386022. Bibcode: 2004Natur.431..873W.
- "MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1". The Journal of Biological Chemistry 280 (7): 5178–87. Feb 2005. doi:10.1074/jbc.M407155200. PMID 15563468.
- "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. Sep 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
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