Biology:PHC2

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Polyhomeotic-like protein 2 is a protein that in humans is encoded by the PHC2 gene.[1][2][3]

Function

In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

PHC2 has been shown to interact with MAPKAPK2,[4] PHC1,[1][5] BMI1[1] and MCRS1.[5]

References

  1. 1.0 1.1 1.2 "Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic". Molecular and Cellular Biology 17 (4): 2326–35. Apr 1997. doi:10.1128/mcb.17.4.2326. PMID 9121482. 
  2. "Identification and characterisation of novel mammalian homologues of Drosophila polyhomeoticpermits new insights into relationships between members of the polyhomeotic family". Human Genetics 111 (4–5): 435–42. Oct 2002. doi:10.1007/s00439-002-0814-3. PMID 12384788. 
  3. 3.0 3.1 "Entrez Gene: PHC2 polyhomeotic homolog 2 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1912. 
  4. "P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity". FEBS Letters 564 (1–2): 205–11. Apr 2004. doi:10.1016/S0014-5793(04)00351-5. PMID 15094067. 
  5. 5.0 5.1 "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode2005Natur.437.1173R. 

Further reading