Biology:PKIA
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
cAMP-dependent protein kinase inhibitor alpha is a protein that in humans is encoded by the PKIA gene.[1][2]
The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported.[2]
References
- ↑ "Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor". Mol Endocrinol 5 (9): 1246–1256. Feb 1992. doi:10.1210/mend-5-9-1246. PMID 1770951.
- ↑ 2.0 2.1 "Entrez Gene: PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5569.
Further reading
- "Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase". J. Biol. Chem. 266 (17): 11158–11162. 1991. doi:10.1016/S0021-9258(18)99142-8. PMID 1710219.
- "Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase". Science 253 (5018): 414–420. 1991. doi:10.1126/science.1862343. PMID 1862343. Bibcode: 1991Sci...253..414K.
- "Tyrosine kinase catalyzed phosphorylation and inactivation of the inhibitor protein of the cAMP-dependent protein kinase". J. Biol. Chem. 262 (7): 3398–3403. 1987. doi:10.1016/S0021-9258(18)61516-9. PMID 2434500.
- "Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase". Proc. Natl. Acad. Sci. U.S.A. 82 (13): 4379–4383. 1985. doi:10.1073/pnas.82.13.4379. PMID 2989819. Bibcode: 1985PNAS...82.4379S.
- "Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase". Proc. Natl. Acad. Sci. U.S.A. 83 (6): 1613–1616. 1986. doi:10.1073/pnas.83.6.1613. PMID 3456605. Bibcode: 1986PNAS...83.1613S.
- "The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated". J. Biol. Chem. 270 (5): 2041–2046. 1995. doi:10.1074/jbc.270.5.2041. PMID 7836431.
- "Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor". J. Biol. Chem. 269 (3): 2316–2323. 1994. doi:10.1016/S0021-9258(17)42170-3. PMID 7905001.
- "Evidence for the importance of hydrophobic residues in the interactions between the cAMP-dependent protein kinase catalytic subunit and the protein kinase inhibitors". J. Biol. Chem. 269 (27): 18128–18133. 1994. doi:10.1016/S0021-9258(17)32426-2. PMID 8027074.
- "HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs". Curr. Biol. 6 (7): 848–854. 1997. doi:10.1016/S0960-9822(02)00608-5. PMID 8805303.
- "PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I". J. Biol. Chem. 274 (9): 5370–5378. 1999. doi:10.1074/jbc.274.9.5370. PMID 10026146.
- "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res. 99 (2): 145–149. 2002. doi:10.1016/S0169-328X(02)00104-3. PMID 11978406.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT)". J. Mol. Biol. 329 (5): 1021–1034. 2003. doi:10.1016/S0022-2836(03)00518-7. PMID 12798691.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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