Biology:PKN3 (gene)

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

PKN3 is a protein kinase C-related molecule and thought to be an effector mediating malignant cell growth downstream of activated phosphoinositide 3-kinase (PI3K). It is thought that chronic activation of the phosphoinositide 3-kinase (PI3K)/PTEN signal transduction pathway contributes to metastatic cell growth and that PKN3 may mediate that growth.1

PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 may represent a target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.

Interactions

PKN3 (gene) has been shown to interact with ARHGAP26.

Further reading

• "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Molecular & Cellular Proteomics 6 (3): 537–47. March 2007. doi:10.1074/mcp.T600062-MCP200. PMID 17192257. 
• "PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase". The EMBO Journal 23 (16): 3303–13. August 2004. doi:10.1038/sj.emboj.7600345. PMID 15282551. 
• "PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family". Journal of Biochemistry 130 (1): 23–31. July 2001. doi:10.1093/oxfordjournals.jbchem.a002958. PMID 11432776. 
• "PKN regulates phospholipase D1 through direct interaction". The Journal of Biological Chemistry 276 (21): 18096–101. May 2001. doi:10.1074/jbc.M010646200. PMID 11259428. 
• "Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha". Biochemical and Biophysical Research Communications 261 (3): 808–14. August 1999. doi:10.1006/bbrc.1999.1116. PMID 10441506.