Biology:POLR2J2
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DNA directed RNA polymerase II polypeptide J-related gene, also known as POLR2J2, is a human gene.[1]
This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J.
Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo.[1]
References
Further reading
- "Human PMS2 gene family: origin, molecular evolution, and biological implications". Dokl. Biochem. Biophys. 408: 175–179. 2006. doi:10.1134/S1607672906030185. PMID 16913423.
- Benga WJ; Grandemange S; Shpakovski GV et al. (2005). "Distinct regions of RPB11 are required for heterodimerization with RPB3 in human and yeast RNA polymerase II". Nucleic Acids Res. 33 (11): 3582–3590. doi:10.1093/nar/gki672. PMID 15987790.
- "[New genes on human chromosome 7: bioinformatic analysis of a gene cluster from the POLR2J family]". Bioorg. Khim. 30 (6): 621–5. 2005. doi:10.1023/b:rubi.0000049773.14555.4c. PMID 15586814.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11". Genomics 79 (6): 809–817. 2002. doi:10.1006/geno.2002.6772. PMID 12036295.
- Grandemange S; Schaller S; Yamano S et al. (2003). "A human RNA polymerase II subunit is encoded by a recently generated multigene family". BMC Mol. Biol. 2: 14. doi:10.1186/1471-2199-2-14. PMID 11747469.
- Cramer P; Bushnell DA; Fu J et al. (2000). "Architecture of RNA polymerase II and implications for the transcription mechanism". Science 288 (5466): 640–649. doi:10.1126/science.288.5466.640. PMID 10784442. Bibcode: 2000Sci...288..640C.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
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